Klin Farmakol Farm. 2014;28(4):152-157
DRESS syndrome induced by allopurinol treatment
- 1 III. interní klinika &ndash, nefrologie, revmatologie, endokrinologie FN a LF UP Olomouc
- 2 Ústav patologie FN a LF UP Olomouc
The authors describe a case of a female patient suffering from the DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)
syndrome which was associated with administration of allopurinol. In addition to skin lesions and typical hematological abnormalities,
an acute renal failure requiring hemodialysis was detected in the patient. Liver and pancreatic injury was also manifested. Cessation
of allopurinol and comprehensive intensive treatment including local and systemic corticosteroids led to a regression of skin lesions,
restoration of diuresis, and improvement of renal function. Functions of the other affected organs were restored, too.
Keywords: DRESS syndrome, allopurinol, acute renal failure, corticosteroids
Published: January 1, 2015 Show citation
