Klin Farmakol Farm. 2015;29(2):49-52

Development of resistance of invasive bacteria related to antibiotic consumption

Milan Kolář¹, Pavlína Štrbová²

¹ Ústav mikrobiologie LF UP a FN Olomouc

² Ústav klinické farmakologie LF UP a FN Olomouc

Increasing resistance of bacterial pathogens to antibiotic therapy represents a serious health problem. It is apparent that an integral part

of the sources of rational antibiotic therapy is surveillance of bacterial resistance. The present study aimed at analyzing the resistance

of invasive bacterial pathogens isolated from blood cultures with respect to consumption of antimicrobial agents. The obtained results

suggest a worrying situation concerning the resistance of certain invasive bacteria to antimicrobial drugs. Despite reduced consumption

of third-generation cephalosporins and fluoroquinolones, the resistance of Klebsiella pneumoniae to these antibiotics continues to rise.

A direct association between increased consumption and bacterial resistance was noted in piperacillin/tazobactam and carbapenems.

In the following period, surveillance of bacterial resistance and adherence to the principles of rational antibiotic therapy are necessary

to slow down the pace of this negative trend.

Keywords: bacteria, blood cultures, resistance, antibiotics

Published: July 1, 2015  Show citation