Klin Farmakol Farm. 2016;30(1):42-43 | DOI: 10.36290/far.2016.009

Antiphospholipid syndrome and thrombosis

Petr Dulíček
IV. interní &ndash, hematologická klinika, FN a LF v Hradci Králové

The case report is about male with incidental detection of lupus anticoagulant antibody and venous thrombosis after surgery.

Deep vein thrombosis developed shortly after cessation of pharmacological thromboprophylaxis. Warfarin therapy was difficult

managed and was associated with hair loss and extension of thrombosis. So that rivaroxaban was introduced and during this

therapy thrombotic veins became patent. Long-term anticoagulation is indicated in this setting.

Keywords: lupus anticoagulans, venous thromboembolism, rivaroxaban

Published: May 30, 2016  Show citation

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Dulíček P. Antiphospholipid syndrome and thrombosis. Klin Farmakol Farm. 2016;30(1):42-43. doi: 10.36290/far.2016.009.
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    References

    1. Bauersachs R, Berkowitz SD, Brenner B, et al. The EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363(26): 2499-2510. Go to original source... Go to PubMed...
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    3. Betancur JF, Bonilla-Abadía F, Hormaza AA, et al. Direct oral anticoagulants in antiphospholipid syndrome: a real life case series. Lupus. 2016 Jan 6. pii: 0961203315624555. Epub ahead of print. Go to original source... Go to PubMed...
    4. Schaefer JK, McBane RD, Black DF, et al. Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: a case series of three patients. Thromb Haemost. 2014; 112(5): 947-950. doi: 10.1160/TH14-03-0272. Epub 2014 Aug 14. Go to original source... Go to PubMed...
    5. Pengo V, Banzato A, Bison E, et al. Efficacy and safety of rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome: Rationale and design of the Trial on Rivaroxaban in AntiPhospholipid Syndrome (TRAPS) trial. Lupus. 2016; 25(3): 301-306. doi: 10.1177/0961203315611495. Epub 2015 Oct 13. Go to original source... Go to PubMed...

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