Klin Farmakol Farm. 2017;31(2):27-30 | DOI: 10.36290/far.2017.012

Herpesviruses and resistance to antiherpetics

Miroslav Fajfr, Vlasta Štěpánová
Ústav klinické mikrobiologie, Lékařská fakulta UK v Hradci Králové a Fakultní nemocnice Hradec Králové

Herpesviruses belong to important pathogens in immunosuppressed population, which lead to increased consumption of antiherpeticsand of course also in increased level of resistant viruses to these therapeutics. This paper review basic informationsabout the most important members of antiherpetics, basic mechanisms resistance to antiherpetics and up to date knowledgeabout resistance prevalence and genomic changes associated to resistance.

Keywords: herpesviruses, antivirals, resistance.

Published: July 1, 2017  Show citation

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Fajfr M, Štěpánová V. Herpesviruses and resistance to antiherpetics. Klin Farmakol Farm. 2017;31(2):27-30. doi: 10.36290/far.2017.012.
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References

  1. Cohen JI. Chapter 135 Introduction to Herpesviridae in Mandell, Douglas, and Bennett's, Principles and practice of infectious diseases, 7th Edition, Churchill Livingstone, 2010. Go to original source...
  2. Whitley RJ. Chapter 37 Other antiviral agents in Finch, Greenwood, Norrby and Whitley's Antibiotic and Chemotherapy: Anti-Infective Agents and Their Use in Therapy, 9th Edition, Elsevier, 2010. Go to original source...
  3. Piret J et Boivin G. Antiviral drug resistance in herpesviruses other than cytomegalovirus. Rev. Med. Virol. 2014; 24: 186-218 DOI:10.1002/rmv.1787. Go to original source... Go to PubMed...
  4. De Clercq E. Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. Biochem Pharmacol. 2004; 68(12): 2301-2315. Go to original source...
  5. Bounaadja L, Piret J, Goijette N et Boivin G. Evaluation of Epstein-Barr virus, human herpes virus 6 (HHV-6) and HHV-8 antiviral drug susceptibilities by use of real-time PCR-based assays. J Clin Microbiol 2013;51:1244-46. DOI:10.1128/JCM.03234-12. Go to original source... Go to PubMed...
  6. Laurain NS and Chou S. Antiviral drug resistance of human cytomegalovirus. Clin Microb Rev 2010; 23(4): 698-712. Go to original source...
  7. Piret J, Boivin G. Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. Curr Opin Infect Dis. 2016; 29(6): 654-662. Go to original source...
  8. Burel S, Aime C, Hermet L, et al. Surveillance of herpes simplex virus reesistance to antivirals: 4-year survey. Antiviral Res 2013; 100: 365-372. Go to original source...
  9. Sauerbrei A, Bohn-Wippert K, Kaspar M, et al. Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2. J Antimicrob Chemother. 2016; 71(1): 6-16. doi: 10.1093/jac/dkv285. Go to original source... Go to PubMed...
  10. Mofin F et Thouvenot D. Herpes simplex virus resistance to antiviral drugs. J Clin Virol 2003; 26(1): 29-37. Go to original source... Go to PubMed...
  11. Hlinomazová Z, Loukotová V, Horáčková M, Šerý O. The treatment of HSV1 ocular infections using quantitative real-time PCR results. Acta Ophthalmol. 2012; 90(5): 456-460. Go to original source...
  12. Topalis D, Gillemont S, Snoeck R, Andrei G. Distribution and effects of amino acid changes in drug-resistant ? and ? herpesviruses DNA polymerase. Nucl Acids Res 2016; 44(20): 9530-9554 doi: 10.1093/nar/gkw875. Go to original source... Go to PubMed...
  13. van der Beek MT, Vermont CL, Brediu RG, et al. Persistance and antiviral resistence of VZV in hematological patients. Clin Infect Dis 2013; 56(3): 335-343. Go to original source... Go to PubMed...
  14. El Chaer F, Shah DP and Chemaly RF. How I treat resistance cytomegalovirus infection in hematopoietic cell transplantation recipients. Blood 2016; 128(23): 2624-2636. Go to original source...
  15. Gilbert C, Boivin G. Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother 2005; 49(3): 873-883. Go to original source... Go to PubMed...
  16. Le Page AK, Jager MM, Iwasenko JM, et al. Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients. Clin Infect Dis. 2013; 56(7): 1018-1029. Go to original source... Go to PubMed...
  17. Vejražková E, Hubáček P, Kutová R, et al. Ganciclovir treatment failure in adult allogeneic hematopoietic stem cell transplant recipients with cytomegalovirus infection-a single centre experience. Epidemiol Mikrobiol Imunol. 2015; 64(3): 160-168.




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