Klin Farmakol Farm. 2017;31(4):29-31 | DOI: 10.36290/far.2017.025

Hyperlipidemia induced by quetiapine causing acute pancreatitis

Stanislava Uríková

Gastroenterologická ambulance, Nemocnice Břeclav

Second- generation antipsychotics are associated with metabolic side effects such as hyperlipidaemia and hyperglycaemia. Acutepancreatitis (AP), caused by the use of quetiapine, is a rare complication of this therapy. A 25-year-old man with schizophreniawho had been treated with quetiapine without any other risk factors in the previous period was acutely admitted to abdominalpain, dyspepsia and dyspnoea. The intake laboratory examination showed significant hyperglycaemia (42 mmol/l), hyponatraemia(116 mmol/l), elevated amylase (8,7 μkat/l) and elevated inflammatory parameters. Computer tomography (CT) of the abdomenconfirmed the diagnosis of mild acute pancreatitis according to the Atlanta classification (1), according to the CTSI score of 6 points,AP was moderate. Further investigation showed hypercholesterolaemia (12,7 mmol/l) and hypertriglyceridaemia (16,2 mmol/l).There was a suspicion of postmedicament etiology. Quetiapine had a significant decrease in cholesterol and triglycerides afterquitting. Patient status improved in conservative therapy and was released to home treatment after 17 days.

Keywords: acute pancreatitis, quetiapine, drug-induced pancreatitis

Published: January 1, 2018  Show citation