Klin Farmakol Farm. 2018;32(3):34-37 | DOI: 10.36290/far.2018.031

Amiodarone induced acute hepatotoxicity during intravenous application

Jana Ďuricová^1,2, Marcela Káňová^3,4, Ivana Kacířová^1,2

¹ Oddělení klinické farmakologie, Ústav laboratorní diagnostiky, FN Ostrava

² Ústav klinické farmakologie, Lékařská fakulta, Ostravská univerzita, Ostrava

³ Klinika anesteziologie, resuscitace a intenzivní medicíny, FN Ostrava

⁴ Ústav fyziologie a patofyziologie, Lékařská fakulta, Ostravská univerzita, Ostrava

Amiodarone is considered a very effective agent in the treatment of supraventricular and ventricular arrhythmias. It has a goodhaemodynamic profile with a low arrhythmogenic risk. However, its use is associated with many cardiac and extracardiac adverseeffects. Hepatotoxicity during long-term amiodarone administration is relatively frequent. Asymptomatic elevation of transaminasesis reported with incidence about 25 %, with normalisation after dose reduction or amiodarone discontinuation. On the otherhand, acute hepatotoxicity during intravenous amiodarone application is rare. This article presents a case of a patient admittedto the intensive care unit of our hospital who developed acute hepatotoxicity shortly after intravenous amiodarone introductionwith a rapid recovery after amiodarone cessation.

Keywords: amiodarone, hepatotoxicity, intravenous application

Received: March 20, 2017; Accepted: March 30, 2017; Published: November 1, 2018  Show citation