Klin Farmakol Farm. 2020;34(1):30-33 | DOI: 10.36290/far.2020.008

Adverse effects of platine derivatives administered by HIPEC method

Šárka Sperottová^1,2

¹ Ústav farmakologie, Lékařská fakulta Univerzity Palackého v Olomouci

² Lékárna Fakultní nemocnice Olomouc

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a method used to treat patients with peritoneum carcinomatosis. Cytostatics used in therapy include platinum derivatives - cisplatin and oxaliplatin. These alkylating chemotherapeutics attack the tumor cell DNA and induce apoptosis. They have a lot of side effects because they affect all of the proliferating cells. Besides typical thrombocytopenia and neutropenia, acute renal failure in cisplatin (36% of patients) or neuropathy in oxaliplatin (19% of patients) may occur. Others include respiratory diseases, wound infections, or hemoperitoneum. During HIPEC, the staff comes directly into contact with a cytostatic agent, which is usually more concentrated than when administered intravenously. It is essential to comply with the safety principles, including the control of sample of urine and blood. Studies show, that platinum derivatives in samples are below the detection limit and that the HIPEC method could be safe. However, studies showing safety in the long term are missing.

Keywords: HIPEC, platinum derivatives, adverse effects, personel safety.

Published: April 8, 2020  Show citation