Klin Farmakol Farm. 2022;36(1):24-28 | DOI: 10.36290/far.2022.005

Antifibrinolytics in cardiac surgery

Roman Hájek
Kardiochirurgická klinika Fakultní nemocnice Olomouc

Cardiac surgery using cardiopulmonary bypass is associated with common activation of whole hemostatic system including fibrinolysis. Antifibrinolytics are the most extensively studied drugs in modern cardiac surgery during the last two decades. There is a strong evidence about their impact on reduction of bleeding and transfusion requirement but some questions about their safety still remain. This article illustrates briefly mechanism of fibrinolysis, effect of aprotinin and lysine analogues and their current place in cardiac surgery.

Keywords: cardiopulmonary bypass, fibrinolysis, antifibrinolytics.

Published: May 5, 2022  Show citation

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Hájek R. Antifibrinolytics in cardiac surgery. Klin Farmakol Farm. 2022;36(1):24-28. doi: 10.36290/far.2022.005.
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