Klin Farmakol Farm. 2024;38(1):38-45 | DOI: 10.36290/far.2024.006

Pharmacological profile of mavacamten in the treatment of hypertrophic obstructive cardiomyopathy

Marek Lapka
Ústav farmakologie, 3. lékařské fakulty Univerzity Karlovy, Praha

Mavakamten is a selective, allosteric and reversible inhibitor of cardiac myosin. In this way, it modulates the number of myosin heads that enter the state of onset of contraction, thereby reduce the likelihood of the formation of systolic and residual diastolic cross bridges during contraction. The molecule is currently approved and indicated for the treatment of symptomatic hypertrophic obstructive cardiomyopathy (oHCM) (New York Heart Association, NYHA, class II-III) in adult patients. A large clinical study is currently underway, which will attempt to supplement the long-term data on the safety and efficacy of mavacamten in the mentioned indication.

Keywords: mavacamten, cardiac myosin inhibitor, cardiac, hypertrophic cardiomyopathy.

Accepted: March 26, 2024; Published: April 8, 2024  Show citation

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Lapka M. Pharmacological profile of mavacamten in the treatment of hypertrophic obstructive cardiomyopathy. Klin Farmakol Farm. 2024;38(1):38-45. doi: 10.36290/far.2024.006.
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