Klin Farmakol Farm. 2025;39(2):117-121 | DOI: 10.36290/far.2025.040
Conservative treatment od endometriosis
- Gynekologicko-porodnické oddělení Nemocnice AGEL Nový Jičín, a. s.
- EuroEndoCert akreditované centrum pro léčbu endometriózy
Endometriosis is a chronic gynaecological condition affecting up to 10 % of women of reproductive age. Fertility disorders, pain, and organ involvement significantly impact the quality of life and health of those affected. The socioeconomic burden is considerable, with substantial resources allocated to treatment. Management includes both radical surgical approaches and conservative methods, namely the administration of various groups of medicinal products. Analgesics are used to alleviate painful symptoms. Hormonal therapies include progestins alone or in combination with oestrogens, which influence the activity of endometriotic lesions. Another group of modern drugs employed in the conservative treatment of endometriosis are GnRH agonists and GnRH antagonists. In particular, GnRH antagonists combined with oestrogen-progestin therapy rank among the most effective treatment options. The article also discusses further possibilities for alternative therapies and outlines the future development of conservative treatment options and diagnostic approaches for endometriosis.
Keywords: endometriosis, estagens, antiflogistic drugs analgesics, GnRH agonist, GnRH antagonist.
Accepted: July 3, 2025; Published: July 4, 2025 Show citation
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