Clinical Pharmacology and Pharmacy, 2024 (vol. 38), issue 3
Original articles
Evaluation of drug-drug interactions in patients with cardiovascular disease and type 2 diabetes while receiving nirmatrelvir/ritonavir
Zuzana Mačeková, Veronika Tomášová, Katarína Pajerová, Peter Takáč, Ondrej Šimandl, Eva Kmoníčková, Ivan Vaňo, Mária Göböová
Klin Farmakol Farm. 2024;38(3):92-99 | DOI: 10.36290/far.2024.015 
Introduction: Co-administration of the nirmatrelvir/ritonavir with cardiovascular medications has a number of drug interactions that can lead to failure of pharmacotherapy for chronic diseases. It is therefore essential to evaluate the risk of interactions that may occur with current chronic pharmacotherapy before indicating this drug. Aim: To identify drug interactions of nirmatrelvir/ritonavir with medication for cardiovascular disease and type 2 diabetes in chronic pharmacotherapy, to assess the risk of potential drug-drug interactions, and to summarize clinically relevant interactions and thereby contribute to the reduction of the risk of adverse...
Main topic
Význam a bezpečnosť suplementácie magnéziom v období tehotenstva.Suplementovať alebo nie?
Kristína Podolská, Dana Mazánková, Mária Göböová
Klin Farmakol Farm. 2024;38(3):100-106 | DOI: 10.36290/far.2024.016
Magnézium (Mg2+) je esenciálny minerál, ktorý sa podieľa na rôznych dôležitých biochemických reakciách v tele matky a plodu. Magnéziová deficiencia v tehotenstve by nemala byť podceňovaná. Počas tehotenstva sú zvýšené požiadavky na príjem magnézia. Hypomagneziémia pozorovaná na zvieracích modeloch umožňuje vyhodnotiť, do akej miery môže nedostatok magnézia ovplyvniť zdravie plodu u ľudí neskoršie v živote. Tento článok sumarizuje dôležitosť magnézia v tehotenstve, zmeny vo farmakokinetike magnézia a dôsledky magnéziovej deficiencie u matky a plodu. Cieľom článku je zodpovedať otázku, či je v tehotenstve potrebná suplementácia magnéziom...
Current trends in pain therapy in burn patients Opioid, non-opioid and non-pharmacological effects on pain
Júlia Bartková, Dušana Selecká, Anna Príbojová, Dominika Miklišová, Bohumil Bakalář, Břetislav Lipový
Klin Farmakol Farm. 2024;38(3):107-111 | DOI: 10.36290/far.2024.017
One of the primary difficulties in treating burn patients lies in efficacious pain management. Pain arising from thermal injury is amalgamated with a multifaceted composition, encompassing acute, neuropathic, inflammatory, and nociceptive traits. Inadequate management of painful stimuli leads to reduced patients' "compliance" and can prolong recovery times with a detrimental impact on the patient's quality of life, given pain's known association with negative perceptions such as fear and anxiety. Opioids are the preferred drug for treating extensive burns. However, administration must consider several crucial factors such as the patient's consciousness...
Biological effects of excipients used in intravenously administered drugs
Jitka Rychlíčková, Lenka Součková
Klin Farmakol Farm. 2024;38(3):112-117 | DOI: 10.36290/far.2024.018
Medicinal products for intravenous administration often contain excipients, in addition to the pharmacologically active substance, that ensure the solubility, stability and correct pH of the drug. Excipients are assumed to be biologically inert, but this assumption is not always met. Some excipients may cause hypersensitivity reactions, organ toxicity, discomfort on administration or show own biological effects The regulatory framework for these substances varies according to their known effects, thus the quantitative content of these substances is not always compulsory to be specified. This article focuses on three frequently used excipients in intravenous...
Review articles
Binding forces: types of drug interactions with molecular targets in organism
Marta Kučerová
Klin Farmakol Farm. 2024;38(3):118-122 | DOI: 10.36290/far.2024.019
The mechanism of action of most drugs is based on their interaction with molecular targets in the organism, i.e., biological macromolecules such as proteins or nucleic acids. Factors influencing the strength of binding of a drug molecule to its biological target include the total number of interactions, their character, and the resulting binding energy. The value of binding energy is an essential parameter for estimating the strength of the interaction. The basic types of these intermolecular interactions are defined, schematically illustrated, and supported with data on binding energy in this review article. Other aspects of drug binding to...
Case report
The Role of the Clinical Research Coordinator in Healthcare Institutions - A Cinderella Among Clinical Trial Experts?
Šárka Selvekerová, Michaela Hanáková, Regina Demlová, Kateřina Nebeská, Helena Krist, Martin Dušek, Naděžda Puškařová, Pavla Nevolová, Petra Brandejsová, Hana Doležalová, Karin Cvikliková, Johana Krempová, Lenka Součková
Klin Farmakol Farm. 2024;38(3):124-131 | DOI: 10.36290/far.2024.020
The article focuses on mapping the current status of clinical research coordinators in healthcare institutions in the Czech Republic. The main objective is to raise awareness of the tasks performed by clinical research coordinators and to identify their educational needs. The study also examines the demand for a formal educational program that would support the professional development of this crucial role in clinical research. The results of two surveys, involving 42 healthcare institutions and 120 clinical research coordinators, show that only 45% of institutions have a formal Clinical Trials Unit. Approximately 40% of clinical research coordinators...