Klin Farmakol Farm. 2012;26(2):61-66

Resistance of Enterobacteriaceae to selected antibiotics in relation to their consumption

Miroslava Htoutou Sedláková¹, Vladimíra Vojtová², Vojtěch Hanulík¹, Hana Suchánková², Milan Kolář¹

¹ Ústav mikrobiologie LF UP v Olomouci a FN Olomouc

² Ústav klinické farmakologie LF UP v Olomouci

The aim of the present study was to analyse the development of resistance of clinically most relevant Enterobacteriaceae in association with

the selection pressure of selected antibiotic groups. We evaluated the development of resistance of K. pneumoniae (a total of 31,627 strains),

E. coli (55,727 strains), E. cloacae (3,251 strains) and P. mirabilis (13,751 strains) in relation to the consumption of third- and fourth-generation

cephalosporins, fluoroquinolones, and piperacilin/tazobactam at the Olomouc University Hospital in the years 2000 to 2010. The resistance

of Enterobacteriaceae to piperacillin/tazobactam was found to increase depending on the consumption of this antibiotic. By contrast, their

resistance to third- and fourth-generation cephalosporins and fluoroquinolones increases despite a reduction in their consumption. The

resistance of Enterobacteriaceae to these antibiotics is likely to be so significant that even a reduction in their consumption has not resulted

in its decrease. The possibility has to be taken into account that the selection pressure of antibiotics, as a factor of spread of bacterial resistance,

has moved to the background, and recombinant processes and transferable genetic elements are beginning to play the major role.

Keywords: resistance, Enterobacteriaceae, antibiotics, fluoroquinolones, cefalosporins, piperacillin/tazobactam, selection pressure

Published: July 31, 2012  Show citation