Klin Farmakol Farm. 2012;26(2):93-97

Daily analgesics, their risks and prospects for development

Milan Kriška
Ústav farmakológie a klinickej farmakológie Lekárskej fakulty Univerzity Komenského, Bratislava

Despite existing WHO's schemes and professional societies' schemes, pharmacotherapy of pain, in addition to high consumption of analgesics,

remains one of the crucial problems of modern medicine due to drug-induced risks. The aim of the paper was to present an opinion on

the role of non-steroidal anti-inflammatory drugs (NSAIDs) and other daily analgesics in relation to other analgesics. Given the low degree

of critical thought of patients as well as health care professionals concerning the selection and use of analgesics, an opinion is required on

the risk of pharmacotherapy with analgesics in everyday clinical practice, also with respect to an increasing risk of developing unexpected

interactions. Because of the topic's complexity in terms of its extent and content and due to inconsistency in evaluating NSAIDs, we shall

confine ourselves, at the suggestion of the Editorial Board, to basic developmental trends with an emphasis on assessing the benefits and risks.

Keywords: analgesics for daily use, NSAIDs, analgesics risk, analgesics innovatious

Published: July 31, 2012  Show citation

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Kriška M. Daily analgesics, their risks and prospects for development. Klin Farmakol Farm. 2012;26(2):93-97.
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References

  1. Henderson H. The paternity of aspirin. Science, 1999; 286: 1089. Go to original source...
  2. Homburg E. The emergence of research laboratories in the dyestuffs industry, 1870-1900. Brit J History Science, 1992; 25: 91-111. Go to original source...
  3. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, New Biology 1971; 231: 230-235. Go to original source... Go to PubMed...
  4. Worldwide use of NSAIDs wvv.nsaid.info.
  5. Libby P, Ridker PM. Inflammation and atherothrombosis: from population biology and bench research to clinical practice J Am Coll Cardiol 2006; 48: 33-46. Go to original source...
  6. Ferenčík M, Štvrtinová V, Bernadič M, a kol. Zápal. horúčka. bolesť. Bratislava, Slovart GTG. Slovak Academic Press 1997: 215.
  7. www.EMA.safety.com.
  8. Griswold DE, Adams JL. Constitutive cyclooxygenase (COX1) and inducible cyclooxygenase (COX-2): rationale for selctive inhibition and progress to date Med Res reviews 1996; 16: 181-206. Go to original source...
  9. Rovenský J, Kriška M. Klinicko-farmakologická charakteristika - lornoxikam. Reumatológia 2009; 23: 105-107.
  10. Fuster V, Cohen M, Halperin J. Aspirin in the prevention of coronary disease. New England J Med 1989; 321: 183-185. Go to original source... Go to PubMed...
  11. Muiswinkel FL, Eikelboom P. Do nonsteroidal-antiinflammatory drugs have a protective effect against dementia? Drugs 1996; 9: 1-7. Go to original source... Go to PubMed...
  12. DuBois D. N Aspirin and breast cancer prevention: the estrogen connection. J Am Med Assoc, 2004; 291: 2488-2489. Go to original source... Go to PubMed...
  13. Arber N, Eagle CJ, Spicak J, a kol. Celecoxib for prevention of colorectal adematous polips New England J Med 2003; 355: 885-895. Go to original source... Go to PubMed...
  14. Imperiale TF. Aspirin and the prevention of colorectal cancer. New England J Med 2003; 348: 879-880. Go to original source... Go to PubMed...
  15. www/Pharmacy.code.com
  16. Bennet PN, Brown MJ. Clinical Pharmacology Churchill Livingstone, Edinburg, 2008: 694. Go to original source...
  17. Drug benefits and risks eds. Boxtel CH, Santoso B, Edwards IR, 2nd Editions UMC collab WHO 2008: 747.
  18. Dubach UC, Levy PS, Minder F. Epidemiological study of analgesic intake and its relationship to urinary disorders in Switzerland Helvetica Med Acta 1950; 17: 464-457.
  19. Sawinok J, Yaksh TL. Pharmacol Reviews 1993; 45: 45-85.
  20. Klinická farmakologie volně prodejných analgetik. Sekce klinické farmakologie České farmakogické společnosti JEP, n.p. Léčiva 1983: 115.
  21. Laska EM, Sunshire A, Marcercero I, et al. The correlation between blood levels of ibuprofen and clinical analgesic response ClinPharmacol Ther 1986; 40: 1-7. Go to original source... Go to PubMed...
  22. Kriška M, Rybár I, Rovenský J. Interakcie nesteroidových antiflogistik a analgetik Klin Farmakol. Farmacie 2004; 2: 108-110.
  23. Basic and clinical pharmacology Eds Katzung BG, Masters SB, Trevor EJ. McGravHill 2009: 1218.
  24. Gizling E. Metamizol Pharma-kritik 2008; 30: 41-43. Go to original source...
  25. www EMA.safety.com.
  26. Zuckerman MJ, Anuras S. Analgesic hepatopathy in Drug induced hepato-toxicity Eds Cameron RG, Feuer G, Inglesias FA, springer, 1996: 515-542. Go to original source...
  27. Kršiak M, Švihovec J, Zupanets I, Kriška M. Optimální dávkování paracetamolu paracetamolu při léčbě bolesti a horečky Farmakologie 2009; 136-138.
  28. Kriška M. Hodnotenie rizika Liekov-vývoj teminológie Klin Farmakol Farm 2011; 25(3): 121-125.
  29. Whelton A, White WB, Bello AE, Puma JA, Fort JG. Effects of celecoxib and rofecoxib on blood pressure and edema in patients over 65 years of age with systemic hypertension and osteoarthritis. Am J Cardiol 2002; 90(9): 959-963. Go to original source... Go to PubMed...
  30. Beilin LJ. Non-steroidal anti-inflammatory drugs and antihypertensive drug therapy. J Hypertens 2002; 20(5): 849-850. Go to original source... Go to PubMed...
  31. Varga Z, Kristova V, Kriska M. Kardiovaskulárne riziko nesteroidových antiflogistík - klinický dopad a možné mechanizmy. Klin Farmakol Farm 2011; 25(3): 131-136.
  32. Horáčková M. Analgetika a ledviny, Triton Praha 2000: 165.
  33. FitzGerald GA. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov. 2003; 2: 879-890. Go to original source... Go to PubMed...
  34. Wolfe MM. Future trends in the development of safer nosteroidal anti-inflammatory drugs Am J Med 1998; 105: 44-52. Go to original source... Go to PubMed...
  35. Ko J. Efficacy and safety of IV tanezumab in osteoarthritis knee and hip. Acsording to lectures Amer Acad pain Med. 30 Ann Meeting, 2011.
  36. Kriška M, Rovenský J, Rybár I. Zlyhanie farmakoterapie pri používaní nesteroidových antiflogistík Reumatologia 2009; 23: 19-26.
  37. Psaty BM, Furberg CD. Cox-inhibitors -lessons in drug safety. Editorial New England Med J 2005; 10: 1056. NEJMe058042.
  38. Hama R. NSAIDs and flu Br. Med J 2009; 338: 2398. Go to original source... Go to PubMed...




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