Klin Farmakol Farm. 2019;33(1):12-18 | DOI: 10.36290/far.2019.031

The therapy of ocular manifestations of immune mediated inflammatory diseases

Aneta Klímová, Petra Svozílková, Michaela Brichová, Eva Říhová, Pavlína Skalická, Jarmila Heissigerová

Oční klinika, 1. lékařská fakulta, Univerzita Karlova a Všeobecná fakultní nemocnice v Praze

Immune mediated inflammatory diseases cause impairment of joints, skin, kidneys, lungs or cause neurological and ocular symptoms. Ocular manifestation of immune mediated inflammatory diseases involves conjunctiva (conjunctivitis), sclera and episclera (scleritis and episcleritis), cornea (keratitis), retina (retinitis), uvea, which comprises iris, ciliary body and choroid (uveitis). Beside the eye, surrounding tissues may be affected – optic nerve, lacrimal gland and soft tissues of the orbit. The severity of ocular impairment may be variable, even sight threatening, sometimes cause discomfort or pain. Local therapy with eye drops, periocular injection or intravitreal application of therapeutics depends on type of ocular manifestation and etiology of systemic disease. In case of severe impairment with high risk of vision loss, the systemic therapy is indicated in cooperation with related specialist.

Keywords: immune mediated inflammatory diseases, ocular impairment, immunosuppressive therapy, DMARDs, biologic therapy

Received: March 13, 2018; Accepted: April 8, 2018; Published: April 25, 2019  Show citation