Klin Farmakol Farm. 2019;33(3):46-49 | DOI: 10.36290/far.2019.036

Metamizole‑affected onset of action of filgrastim

Anna Oleárová^1,2, Katarína Jurečková¹

¹ Oddelenie klinickej farmakológie, Univerzitná nemocnica Bratislava, Nemocnica Ružinov, Bratislava

² Ústav farmakológie a klinickej farmakológie, Lekárska fakulta, Slovenská zdravotnícka univerzita v Bratislave

Metamizole is widely used analgesic with antipyretic and spasmodic effect. Metamizole is not used in many countries because of the risk of agranulocytosis. We describe a case study of 72-years old female admitted with severe pancytopenia and treated with colony-stimulating factor filgrastim. The effect of filgrastim has been affected by the concomitant use of metamizole. The pharmacotherapy was revised and the risky metamizole was stopped. The therapy continued with two doses of filgrastim, and numbers of leukocytes and neutrophils increased satisfactorily. The therapy was supported with blood derivatives and patient has been discharged as stabilised.

Keywords: metamizole, filgrastim, agranulocytosis, pancytopenia, interaction

Received: May 2, 2018; Accepted: May 9, 2018; Published: October 28, 2019  Show citation