Klin Farmakol Farm. 2020;34(1):23-29 | DOI: 10.36290/far.2020.007

Skin adverse drug events - allergic reactions

Karel Ettler1, Jiří Ettler2
1 Klinika nemocí kožních a pohlavních LF UK a FN Hradec Králové
2 3. lékařská fakulta UK, Praha

Skin exanthema represents one of the most frequent adverse drug reactions. Pharmacologic and idiosyncratic (including allergic reaction especially after repeated exposition) reactions according to mechanisms are mentioned. Four types of allergic reactions are distinguished - the IV. type is the most frequent (including the most severe epidermal necrolysis). The first step in patient´s management is withdrawing of the drug. Topical dermatological treatment depends on type of exanthema. Systemic therapy (antihistamins, steroids, immunosuppressives, IVIG, biologics) is used in severe cases. The records to the patients documentation (allergy pass) are crucial for prevention of repeated adverse events.

Keywords: cutaneous adverse drug reactions, SJS, TEN, diagnostic tests.

Published: April 8, 2020  Show citation

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Ettler K, Ettler J. Skin adverse drug events - allergic reactions. Klin Farmakol Farm. 2020;34(1):23-29. doi: 10.36290/far.2020.007.
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    References

    1. Abrams EM, Khan DA. Diagnosing and managing drug allergy. CMAJ, 2018; 190(17): E532-E538. Go to original source... Go to PubMed...
    2. Pichler WJ, Hausmann O. Classification of Drug Hypersensitivity into Allergic, p‑i, and Pseudo‑Allergic Forms. Int Arch Allergy Immunol 2016; 171: 166-179. Go to original source... Go to PubMed...
    3. Montanez MI, Mayorga G, Bogas G, et al. Epidemiology, mechanisms, and diagnosis of drug‑induced anaphylaxis. Front Immunol 2017; 9: 614. Go to original source...
    4. Nemšovská J. Liekové hypersenzitivne reakcie: klasifikácia a patogenéza (1.časť). Čes‑slov Derm 2019; 94(3): 99-106.
    5. Ardern‑Jones M, Friedmann PS. Skin manifestations of drug allergy. Br J Clin Pharmacol 2010; 71(5): 672-683. Go to original source...
    6. Kováčová S. DIHS - liekmi indukovaný hypersenzitívny syndróm. Dermatol Prax 2014; 8(2): 40-64. Go to original source...
    7. Nemšovská J. Liekové hypersenzitivne reakcie: diagnostika a liečba (2.časť). Čes‑slov Derm 2019; 94 (5): 192-202.
    8. Mayorga C, Celik G, Rouzaire P. et al. In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy 2016; 71: 1103-1134. Go to original source... Go to PubMed...
    9. Crisafulli G, Franceschini F, Caimmi S, Bottau P, Liotti L, Saretta F, Bernardini R, Cardinale F, Mori F, Caffarelli C. Mild cutaneous reactions to drugs. Acta Biomed 2019; 90(Suppl. 3): 36-43.
    10. Barbaud A. Skin testing and patch testing in non‑IgE‑mediated drug allergy. Curr Allergy Astma Rep 2014; 442(14): 1-8.
    11. Friedmann P. S., Ardern‑Jones M. Patch testing in drug allergy. Curr Opin Allergy Clin Immunol 2010; 10: 291-296. Go to original source... Go to PubMed...
    12. Scherer K., Brockow K., Aberer W. Desensitization in delayed drug hypersensitivity reactions - an EAACI position paper of Drug Allergy Interest Group. Allergy 2013; 68(7): 844-852. Go to original source...

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