Klin Farmakol Farm. 2023;37(3):93-101 | DOI: 10.36290/far.2023.017

Individual pharmacokinetic modelling and therapeutic drug monitoring

Blanka Kořístková^{1, 2}

¹ Ústav klinické farmakologie, Lékařská fakulta, Ostravská univerzita, Ostrava

² Oddělení klinické farmakologie, Ústav laboratorní medicíny, Fakultní nemocnice Ostrava

Therapeutic drug monitoring allows the adjustment of the patient's dosage based on the drug concentration. Pharmacokinetic modelling software enables to predict the concentrations with regular and irregular dosing, with non-standard sampling times, before reaching a steady state or with changing function of elimination organs, in particular kidneys. Unexpected results can be caused by a sampling error (esp. when sample was taken from the same site as the drug was administered, or sampling from a central venous catheter), an incomplete drug history during dosage changes before sampling, missing information on the use of a loading dose, or a drug interaction. A specific case is the administration of the drug to dialysis patients, where a significant dose reduction is necessary in intermittent dialysis, while in continuous dialysis the dosage is proportional to serum creatinine values. To correctly interpret the results, correct and complete input data of the patient and, in particular, a full dose history are necessary.

Keywords: PK/PD modelling, pharmacokinetic analysis, Mw\\Pharm, TDM.

Accepted: October 12, 2023; Published: October 13, 2023  Show citation