30 let klinické farmakologie ve zdravotnických zařízeních České republiky

Milan Grundmann

Klin Farmakol Farm. 2008;22(4):127-129  

Knowledge, perception of risks and compliance of patients using systemically administered glucocorticoids: a questionnaire study

Karel Urbánek, et. al

Klin Farmakol Farm. 2008;22(4):132-135  

Systemically administered glucocorticoids are effective drugs used in the therapy of autoimmune diseases and in many acute states. Sufficient knowledge, compliance and lifestyle changes can increase efficacy and decrease unwanted effects of the treatment in long-term glucocorticoid users. The aim of this study was to investigate knowledge, compliance and perception of risks in patients using systemic glucocorticoids. A questionnaire survey was conducted in out-patients treated for rheumatic, GIT or blood disease. Sixty four patients were interviewed; their average age was 42,7 years (19–73) and 59 % of them were women. Majority of respondents...

Editorial

Zdeněk Hájek

Klin Farmakol Farm. 2008;22(4):136  

Antibiotic treatment and prophylaxis of some infections in pregnancy

Jaromír Mašata, et. al

Klin Farmakol Farm. 2008;22(4):137-141  

Article serves summary about the negative influence of some infections on pregnancy and foetus. It also deals with influence of subclinical intrauterine infections on the development of the premature labour and preterm prelabour rupture of membranes (PPROM) and offer recommended procedure at PPROM. Furthers describes relation of bacterial vaginosis and possible role of aerobic vaginitis on the onset of premature labour. Other important part of contemporary obstetrics is also adequate prepartal prophylaxis of neonatal GBS infections.

TREATMENT OF PRETERM LABOR - TOCOLYTICS AND CORTICOSTEROIDS

Zdeněk Hájek

Klin Farmakol Farm. 2008;22(4):142-144  

Using tocolytics and corticosteroids accounts for the basic treatment of preterm labor. The successful of tocolytic therapy is to postpone premature labor for at least 48 hours to induce lung maturition with corticosteroids and to transport mother to the regional centre. Such as treatment means, the essential change in management of preterm births and significantly decreases the mortality and morbidity of the prematurely delivered newborns.

Pharmacological prevention of bleeding at caesarean section

Antonín Pařízek

Klin Farmakol Farm. 2008;22(4):145-148  

During Caesarean sections, a blood loss of less than 1000 mL can be considered appropriate. The incidence of serious forms of excessive postpartum bleeding, i.e., of those associated with increased maternal mortality or significant morbidity (a blood loss greater than 1500 mL at Caesarean section), is reported to be 1/1000 and 3.5–5/1000 live births in developed and developing countries, respectively. In developing countries, more than 100,000 women die from this obstetric complication every year. The introduction of the prophylactic administration of uterotonic drugs during the third stage of labour results, even in the case of a Caesarean section,...

Contraindications in gynecological practice

Michael Fanta

Klin Farmakol Farm. 2008;22(4):149-152  

Review article presenting summary of contraceptive methods and modalities available in our market, their properties, contraindications, reliability and additional positive effects.

Vaccination against HPV

Jiří Sláma

Klin Farmakol Farm. 2008;22(4):153-155  

Cervical cancer ranks second in deaths from cancer among women worldwide. Persistent high risk HPV infection has been strongly linked to causing cervical carcinoma. Prophylactic vaccines are targeted to prevent the infection caused by most common high risk genotypes of HPV – 16 and 18, which are associated with approximately 70% of cervical cancers. Seroconversion was seen in 100% of cases after administration of all three doses. Seroconversion is independent of age and HPV DNA status at the entry. Detection of high level of specific antibodies is determined by adjuvant system included in vaccine. Both vaccines show 100% efficacy against lesions...

Hormone replacement therapy update

Tomáš Fait

Klin Farmakol Farm. 2008;22(4):157-160  

Hormone replacement therapy with the lowest dosage, early start and individual approach is the first-choice drug for acute climacteric syndrome. It have been safety for cardiovascular disease so as for breast cancer in acceptance of contraindications. The early start of therapy is connected with lowering of cardiovascular risk in the sharp difference from later iniciation. Hormone replacement therapy should be given to the basic possition of osteoporosis prevention in connection with vitamine D and calcium intake. For therapy of urogenital atrophy we prefer the low-doses vaginal therapy. The rational and safety hormonal substitution are based on annualy...

Pharmaceutical care and its applications in clinical praxis

Lívia Magulová, et. al

Klin Farmakol Farm. 2008;22(4):161-164  

Safety of the pharmacotherapy depends on the detection of the risk of drugs and the risk factors of individual patients and on the effective prevention of the drug induced injury in the praxis. Pharmacists can play an important role in providing effective and safe pharmacotherapy and prediction of its risks as well as drug interactions and adverse events. By giving the adequate information about the medicine, they can increase patients’ compliance. To provide more complex pharmaceutical care it is necessary to improve the communication between the pharmacist and patient as well as the pharmacist and the medical doctor and other health care professionals....

Komentář ke článku „Očkování proti HPV“

Marek Petráš

Klin Farmakol Farm. 2008;22(4):156  

Zpráva z X. sympozia klinické farmacie René Macha „Vinobraní“ zkušeností

Petra Matoulková, et. al

Klin Farmakol Farm. 2008;22(4):172-173  

Present experience from previous check prescription

Lubomír Dvořáček

Klin Farmakol Farm. 2008;22(4):165-168  

Recently there are no studies in the CR focused on assessing the quality of pharmacotherapy, especially with focus on drug interactions, prescription of related ATC groups or on occurence of other abnormalities in prescription. Simoultaneously there are no statistics of hospitalizations due to undesirable drug effects – therefore the existing situation in quality of drug prescription can currently only be appraised or deduced from foreign experience (Pirmohamed M: BMJ 2004; 329: 15–19). The cited study from the team of the professor of clinical pharmacology at University Liverpool Munir Pirmohamed assesses the situation in two big general...