Slovo úvodem

MUDr. Karel Urbánek, Ph.D.

Klin Farmakol Farm. 2015;29(4)  

Use, attitudes and public knowledge toward dietary supplements in Slovakia

Tatiana Kimáková, Lenka Hrnková, Zuzana Koblišková

Klin Farmakol Farm. 2015;29(4):156-161  

Objective of study: The purpose of the study was to evaluate the use of dietary supplements by general public in Slovakia, to identify their attitudes and knowledges towards these products. Methods: A questionnaire survey of 256 respondents was conducted in the time span of October to December 2014 by on-line collection. The use of dietary supplements and knowledges of respondents as their agreement with general, safety and efficacy claims regarding to dietary supplements were evaluated. The results were processed using descriptive Microsoft Excel. Results: Up to 64.5% of the respondents use dietary supplements sometimes (49.8%). Pharmacy...

Direct oral anticoagulants

Karolína Burdová

Klin Farmakol Farm. 2015;29(4):138-143  

For fifty years warfarin was the only available oral anticoagulant. This drug had a significant effect on the prognosis of the patients with atrial fibrillation, venous thromboses and arteficial valve replacements. For the treatment of the patients with anarteficial valve replacement, warfarin remains the only possibility, for the other indications several alternatives have recently emerged. The new oral anticoagulants (NOACs) – dabigatran, rivaroxaban and apixaban – have some advantages compared to warfarin: simple and unitary dosage regimen, good safety and no need for a regular effect monitoring. The NOACs have some specific...

Direct oral anticoagulants in the therapy of venous thromboembolism

Petr Dulíček

Klin Farmakol Farm. 2015;29(4):144-147  

Heparin and antagonists of vitamin K were therapy of choice of venous thromboembolism for many years. Nowadays we can also use in therapy direct anticoagulants which make treatment more comfotable not only for patients, but also for doctors. In the article, we discuss therapy of thrombosis with all new three anticoagulants.

Should dual bronchodilation be the first choice in the treatment of chronic obstructive pulmonary disease?

Štefan Laššán, Monika Laššánová

Klin Farmakol Farm. 2015;29(4):148-152  

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease with increasing morbidity and mortality, which leads inevitable to the need for personalising the assessment and treatment of patients with COPD. Inhaled bronchodilators are the most important drugs used for the treatment of COPD. In particular, these therapeutic agents are mostly long-acting muscarinic receptor antagonists (LAMA) and long-acting β2-adrenoceptor agonists (LABA). Because LAMA and LABA are characterized by different mechanisms of action, results in a synergistic enhancement of their clinical and functional effects. This review discuss that...

Estimated glomerular filtration rate in adult patients

Tomáš Šálek

Klin Farmakol Farm. 2015;29(4):153-155  

Glomerular filtration rate (GFR) is the most important parameter of kidney function. Knowledge of GFR is very important for dosing of drugs excreted by kidneys. It may be useful for therapeutic drug monitoring (TDM). The reference method for measurement of GFR is inulin clearance, but this method is not available in current routine clinical practice. Serum creatinine and cystatin C are available markers in daily clinical practice. Estimated glomerular filtration rates (eGFR) from these markers are used. CKD-EPI equations are recommended for calculation of eGFR in adult patients.