Dobré zprávy ze špatné doby

Karel Urbánek

Klin Farmakol Farm. 2021;35(4):99  

New trends in the approach to the treatment of type 2 diabetes - observations and benefits in the outpatient practice of a diabetologist

Pavel Weber, Hana Meluzínová, Dana Weberová

Klin Farmakol Farm. 2021;35(4):118-123 | DOI: 10.36290/far.2021.027  

Introduction: Type 2 diabetes mellitus (DM2T) constitutes an increased risk of developing micro- and macroangiopathic complications. New antidiabetics have higher efficacy and safety, fewer side effects and a number of protective characteristics of use in many ways. Patients and methods: In the years 2011-2021, about 2000 DM2Ts were permanently treated in our diabetological surgery. In 2021 it was a total of 2,562 of all registered diabetics. Of this number, there were 2,398 cases of T2DM (1,203 men and 1,195 women). A total of 2110 type 2 diabetics (88%) of a mean age of 69.7 ± 11.6 years were treated with antidiabetic drugs, incretin mimetics...

Antithrombotic therapy in antiphospholipid syndrome, the role of direct oral anticoagulants

Jana Hirmerová

Klin Farmakol Farm. 2021;35(4):101-105 | DOI: 10.36290/far.2021.024  

Antiphospholipid syndrome (APS) is an autoimmune, acquired hypercoagulable disorder. It is characterized by a presence of antiphospholipid antibodies (APA) and heterogeneous clinical manifestations, dominated by thrombosis (venous, arterial or small vessel thrombosis) and/or pregnancy complications. Because of high risk of thrombosis recurrence, secondary antithrombotic prophylaxis is of critical importance. Anticoagulation represents the cornerstone of therapy, including the cases of arterial thrombosis. Warfarin remains the first-choice therapy, usually with target INR (international normalized ratio) 2-3. Direct oral anticoagulants (DOACs) are not...

Rheumatic side effects of cancer immunotherapy with immune checkpoint inhibitors

Radoslav Roman

Klin Farmakol Farm. 2021;35(4):106-111 | DOI: 10.36290/far.2021.025  

Immune checkpoint inhibitors (ICI) are effective in therapies for many neoplasias. However, their great antitumor response is frequently associated with adverse events development. Any organ can be affected. The review summarizes the common and also the less frequent rheumatic immune-related adverse effects due to cancer immunotherapy and their management.

A case of difficult to treat psoriatic arthrtitis

David Suchý

Klin Farmakol Farm. 2021;35(4):112-117 | DOI: 10.36290/far.2021.026  

Psoriatic arthritis (PsA) is a chronic autoimmune inflammatory disease manifested by involvement of the musculoskeletal system and skin. PsA is considered part of the spondyloarthritis group, which is present in 20-30%of individuals with psoriasis. The introduction of biological therapy has brought substantial improvement in the prognosis of patients not responding to conventional treatment. The success of affecting the tumour necrosis factor α with therapeutic monoclonal antibodies has been followed by extensive research into other potentially suitable molecules. Secukinumab has become the first monoclonal antibody against interleukin-17A introduced...

The Importance of Penetration Enhancers choice in Topical Products

Jiří Slíva

Klin Farmakol Farm. 2021;35(4):126-129 | DOI: 10.36290/far.2021.029  

Topical products are widely used in the treatment of pain or inflammatory and degenerative conditions. Their undeniable advantage is sufficiently proven clinical efficacy and also a generally favourable safety profile due to their minimal systemic exposure compared to orally used products. It was also demonstrated that exact formulation used is critical for topical analgesic in management of pain conditions. This brief overview emphasizes the important role of different excipients like penetration enhancers which chemical properties suggesting a different disrupting effect on the skin barrier. It summarizes the well-known properties of the skin as...

Komentář k článku „Nové trendy v přístupu k léčbě diabetu 2. typu -postřehy a benefity v ambulantní praxi diabetologa“

Milan Kvapil

Klin Farmakol Farm. 2021;35(4):124-125