Comparison of Mw\Pharm 3.30 (DOS) and Mw\Pharm ++ (Windows) Versions of Pharmacokinetic Software for PK/PD Modelling of Vancomycin in Continuous Administration

Marcela Hricova, Blanka Koristkova, Eliska Vavreckova, Ivana Kacirova, Hana Brozmanova, Milan Grundmann

Klin Farmakol Farm. 2022;36(3):85-92 | DOI: 10.36290/far.2022.014  

Objective: For a long time, the Mw\Pharm software suite (MEDI\WARE, Prague, Czech Republic/Groningen, Netherlands) has been used for PK/PD modelling in therapeutic drug monitoring (TDM). The aim of this study was to find the best model in the newer Windows version of Mw\Pharm++ 1.3.5.558 (WIN) for continuous administration of vancomycin. Patients: Twenty adult patients with a mean age of 66 ± 12 years, body weight 85 ± 16 kg, and median dose 1,625 g/24 h were repeatedly examined for vancomycin.  Methods: Concentrations predicted by “#vancomycin_adult_k_C2”, “#vancomycin_adult_C2”, “vancomycin_adult_C2”,...

Is pharmacological eradication of HIV possible?

Svatava Snopková, Petr Husa, Šárka Kozáková

Klin Farmakol Farm. 2022;36(3):93-100 | DOI: 10.36290/far.2022.015  

The rapid onset of the global HIV pandemic at the turn of the 1980s and 1990s made the disease one of the most studied infectious diseases in the history of medicine. This was also reflected in the rapid development of effective antiretroviral drugs. Antiretroviral therapy has been in clinical practice since 1996. Treatment has significantly prolonged and improved the lives of people living with HIV, saving and still rescuing millions of people infected worldwide. However, after more than twenty years, it is evident that the treatment provided with the current pharmacotherapy is not entirely optimal and has its limits. Its potential is only suppressive,...

COVID-19 and the lung: from interstitial pneumonia to pulmonary fibrosis

Štefan Laššán, Monika Laššánová

Klin Farmakol Farm. 2022;36(3):101-107 | DOI: 10.36290/far.2022.016  

The novel coronavirus-induced disease led to a pandemic that poses a global threat to human health. The most common cause of hospitalisation for COVID-19 is interstitial pneumonia that may be complicated by Acute Respiratory Distress Syndrome (ARDS). The monitoring of patients who have recovered from COVID-associated pneumonia demonstrates that the significant reduction in diffuse lung capacity and associated fibrotic signs in the lung parenchyma are factors associated with a negative prognosis. Thus, the long-term consequences of COVID-19 appear crucial. Risk factors, histopathological characterization, prevalence, and management of post-COVID-19...

Use of taurolidine in the prevention and treatment of catheter infections

Jakub Víšek, Lenka Ryšková, Alena Machačová, Martina Maříková, Vladimír Blaha

Klin Farmakol Farm. 2022;36(3):108-110 | DOI: 10.36290/far.2022.017  

The venous catheter is used for a variety of medical procedures. A dangerous complication of an implanted catheter with potentially very serious consequences is a catheter infection. Antimicrobial locks are used in the prevention and treatment of these infections. Taurolidine [bis- (1,1-dioxoperhydro-1,2,4-thiadiazinyl-4) -methane] is a derivative of the amino acid taurine. This substance replaces previously used antimicrobial locks with ethanol or antibiotics. It has broad antimicrobial effects. The mechanism of action is the binding of the hydroxymethyl group to the cell wall of the microorganism, which leads to its irreversible damage. The preventive...

Neonatal abstinence syndrome: window to the latest treatment practice out of The Czech Republic

Kateřina Olga Koutská

Klin Farmakol Farm. 2022;36(3):111-114 | DOI: 10.36290/far.2022.018  

Introduction: The article summarizes the latest findings in the pharmacological treatment and non-pharmacological care of neonatal abstinence syndrome (NAS), diagnosis P96.1. Methods: This article reviews randomized clinical trials on the therapeutic treatment of NAS with the active substances morphine, methadone, buprenorphine, phenobarbital and clonidine with parameters of treatment duration and length of hospital stay. The source for this article is freely accessible publications searchable in the medical bibliographic database PubMed. Results: The progressive increase in scientific works in the field of treatment optimization about the median length...

Lercanidipine overdose

Marek Pecha, Vladimír Halouzka, Lukáš Daniš, Peter Ondra

Klin Farmakol Farm. 2022;36(3):115-117 | DOI: 10.36290/far.2022.019  

The case report describes a case of poisoning with lercanidipine, a widely prescribed drug from the group of calcium channel blockers. It follows the case of a 31-year-old man who took 90-100 tablets, equivalent to 900-1000 mg, in a suicide attempt. This is the highest administered dose known yet. The patient was given a gastric lavage, administered activated charcoal and Fortrans (macrogol) to speed up drug elimination. Subsequently, CaCl₂ was administered while ionized calcium levels were monitored. After 3 days in the ICU, the patient could be transferred to the psychiatric ward and discharged to home care after less than a week.

Vzpomínky na prof. RNDr. Jaroslava Květinu, DrSc., Dr.h.c. 

prof. MUDr. Jiří Vítovec, CSc., prof. RNDr. Pavel Anzenbacher, DrSc.

Klin Farmakol Farm. 2022;36(3):118-119