Editorial

Jiří Kassa

Klin Farmakol Farm. 2023;37(4):147-148  

Phytic acid - beneficial or not?

Veronika Frýbortová, Eva Anzenbacherová, Pavel Anzenbacher

Klin Farmakol Farm. 2023;37(4):149-151 | DOI: 10.36290/far.2023.025  

Phytic acid (IP6, inositol hexaphosphate) is the most abundant inositol phosphate in nature. It is present mostly in plants but it has ben found also in mammalian cells. IP6 is extensively studied because of enormous variety of its properties. It binds polyvalent cations which was formerly considered as disadvantage responsible for lowered bioavailability of minerals in food. On the other hand, its stucture allows it to act as a natural antioxidant. Protective effect of IP6 has been found in varoius pathologies incl. neuorodegenerative disorders, urolithiasis as well as in malignancies.

Calcium channel blocker intoxications

Marek Pecha

Klin Farmakol Farm. 2023;37(4):152-155 | DOI: 10.36290/far.2023.026  

Calcium channel blocker intoxications are not common despite their widespread use, but are often severe and have a high mortality. In any intoxication, the cause should be investigated to prevent recurrence. This is particularly relevant for suicidal intent. Hypotension is the most common manifestation of poisoning, often accompanied by hyperglycaemia. The effect on heart rate depends on the specific drug and the dose ingested. The treatment is individually tailored according to the severity of intoxication, clinical condition and comorbidities - from observation and intestinal decontamination, through specific therapy - calcium and insulin administration...

Pain associated with neurological occupational diseases

Edvard Ehler

Klin Farmakol Farm. 2023;37(4):156-159 | DOI: 10.36290/far.2023.027  

Many neurologic diseases are associated with occurence of pain of various intensity and various localizations. There is not only nociceptive pain, developed in tissue damage, but also neuropathic pain, peripheral and central. In neurologic occupational diseases pain is a characteristic and frequent feature. Low back pain as an occupational disease is charaterized not only as radicu­lar pain but also as nociceptive pain. In neuropathies and entrapment syndromes neuropathic pain prevailes, often with other sensory symptoms. Focal dystonias are associated with pain irradiated from muscles and other vertebral and articular structures. Inflammatory occupational...

Surgical treatment of bicalutamide-induced gynecomastia, an overview of selected drugs causing unwanted effects of gynecomastia

Júlia Bartková, Dominika Miklišová, Miroslava Verbat, Ema Šutaková, Alžběta Novotná, Zuzana Jelinková, Bretislav Lipový

Klin Farmakol Farm. 2023;37(4):160-164 | DOI: 10.36290/far.2023.028  

Gynecomastia, the enlargement of male breast tissue, is usually caused by hormonal imbalances between estrogen and testosterone levels. However, it can also be caused by a multitude of factors, such as tumors, obesity, hypogonadism, androgen insensitivity syndrome, thyrotoxicosis, or the use of numerous medications. As an example, we present a patient with gynecomastia which developed after a long-term treatment with bicalutamide for prostate cancer. Due to this adverse effect of his medication, our patient experienced significant anxiety and discomfort in his daily life. Therefore, a bilateral mastectomy in combination with liposuction was chosen...