Klin Farmakol Farm. 2008;22(2):55-57

RESISTANCE OF COMMUNITY-ACQUIRED STREPTOCOCCUS AGALACTIAE STRAINS TO MACROLIDE ANTIBIOTICS

Luboslava Čekanová¹, MUDr. Vladimír Zbořil CSc²

¹ Laboratoře Mikrochem a. s. Olomouc

² III. interní klinika gastroenterologická, FN Brno-Bohunice

In order to determine the rates of Streptococcus agalactiae resistance to selected antibiotics, 612 Streptococcus agalactiae strains were isolated from vaginal swabs, 156 from upper respiratory tract, and 97 were obtained from urine samples of patients from the community setting between January and December 2006. The bacterial strains isolated were identified using standard microbiological methods. Susceptibility to antibiotics was determined by the disk diffusion method, the phenotype of resistance to macrolide antibiotics was detected by the D-test. The mean values of resistance to erythromycin, clindamycin, and tetracycline were 25.8 %, 24.1 %, and 82.9 %, respectively. The constitutive phenotype of resistance (cMLSB), inducible phenotype (iMLSB), and efflux (M phenotype) mean values were 79.8 %, 13.6 %, and 6.6 %, respectively. The data obtained confirm the problem of resistance to macrolides and lincosamides in Streptococcus agalactiae species in the community setting. The MLSB resistance phenotype was found in 93.4 % of all erythromycin-resistant strains, which in the case of patients allergic to penicillins and cephalosporines poses a therapeutic challenge.

Keywords: Key words: Streptococcus agalactiae, community setting, antibiotic resistance.

Published: January 1, 2009  Show citation