Farmakoterapie v gynekologii

Pavel Ventruba

Klin Farmakol Farm. 2005;19(4):199  

Potential predictive significance of insulin resistance syndrome in ischemic stroke

Ivanka Vlachová, prof. MUDr. Helena Vaverková CSc, doc. MUDr. Roman Herzig Ph.D, Daniel Novotný, MUDr. Bohdan Křupka Ph.D, doc. MUDr. Věra Krčová CSc, MUDr. Andrea Bártková, Daniel Šaňák, RNDr. Marie Budíková, Karel Urbánek, Petr Kaňovský

Klin Farmakol Farm. 2005;19(4):202-205  

Insulin resistance syndrome (IRS), the incidence of which has been steadily rising, represents a significant risk factor of cardiovascular disease, including ischemic cerebrovascular stroke. The goal of the study was to assess its presence in the acute phase of stroke and evaluate its influence on the severity of neurologic deficit in this phase and later on. Methods: Diagnosis of IRS was made according to NCEP-ATP III criteria including abdominal obesity (waist circumference > 102 cm in men, > 88 cm in women), triglycerides ≥ 1.7 mmol/l, HDL-cholesterol

THERAPY MONITORING OF ASTHMA PATIENTS IN THE PHARMACY

Božena Macešková, Daniela Fridrichová

Klin Farmakol Farm. 2005;19(4):206-210  

The therapy of 16 patients with asthma was monitored within an 8-month period during which the patiens were visiting the same pharmacy. Their medication problems, imperfection in the inhalation technique, and manifestations and reasons of non-compliance were identified in the course of four sessions. The changes in their understanding of the illness and objective changes in their health condition were detected using semistructured interviews. Mistakes in the use of different types of inhalators were minimized, and a training in cleaning the inhalators and in finding out the number of the remaining doses was provided. Eight patients (50.0 %) were feeling...

Immunomodulation in recurrent respiratory infections

doc. MUDr. Jaromír Bystroň CSc

Klin Farmakol Farm. 2005;19(4):235-238  

The auhor gives a brief overview of the most common causes of recurrent respiratory infections, mentions the principles of treatment for these conditions, and discusses the options of immunomodulation which can be used in the treatment of these conditions.

Side effects and interactions of new antiepileptics

doc. MUDr. Vladimír Komárek CSc

Klin Farmakol Farm. 2005;19(4):239-240  

The aim of rational pharmacotherapy of epilepsy is to maximize effectiveness as well as to minimize side effects. In comparison with old antiepileptic drugs (1st and 2nd generation), the side effects and interactions of new „3rd generation“ antiepileptics are less known. The overview of efficacy and tolerability of new antiepileptic drugs (gabapentin, lamotrigine, topiramate, levetiracetam, occarbazepine, tiagabine, zonisamide) is based on a metanalysis of 1 462 publications. In terms of interactions, the slow degradation of lamotrigine due to a combination with valproate is stressed.

55. Česko-Slovenské farmakologické dny

Mgr. Martin Kuneš, prof. RNDr. Dr.h.c. Jaroslav Květina DrSc

Klin Farmakol Farm. 2005;19(4):242  

10. Česko-Slovenská mezioborová toxikologická konference, Olomouc, 14.-16. 9. 2005

Pavel Anzenbacher

Klin Farmakol Farm. 2005;19(4):243  

Publikace českých autorů v JAMĚ upozornila na časté užití léčiv nevhodných ve stáří

Mgr. Daniela Fialová

Klin Farmakol Farm. 2005;19(4):244  

Správa z II. Slovensko-českej konferencie klinickej farmakológie

Jana Tisoňová, Monika Laššánová, Martin Wawruch, Lívia Magulová, Milan Kriška

Klin Farmakol Farm. 2005;19(4):245  

Sto let učebnice FARMAKOLOGIE - Karel Chodounsky, Praha, Bursík a Kohout 1905, stran 466

Peter Višňovský, doc. RNDr. PhMr. Václav Rusek CSc

Klin Farmakol Farm. 2005;19(4):246  

AROMATASE - TARGET OF ANTI-HORMONAL THERAPHY

Petr Hodek, Julie Fidlerová, Marie Stiborová

Klin Farmakol Farm. 2005;19(4):211-214  

The most frequent cancer cases include breast and prostate tumors. These occur in tissues exposed to relatively high concentrations of the oestrogens. As oestrogens are known cell proliferators, it might be possible to reduce the risk of this particular cancer as well as to prolong survival of cancer patients by decreasing the oestrogen concentration or its impact. There are two basic ways how to interfere with biosynthesis or oestrogen targets. The first one is based on the reduction of activity of cytochrome P450 (aromatase), the enzyme that catalyses aromatization of androgens resulting in oestrogens, via down – regulation of the enzyme expression...

hormonal treatment OF Early breast cancer

Jindřich Fínek, Luboš Holubec jr, Lucie Elgrová

Klin Farmakol Farm. 2005;19(4):216-220  

Hormonal therapy is a potent breast cancer treatment in both neoadjuvant and adjuvant form as well as in the treatment of advanced disease.

HORMONAL CONTRACEPTION

Petr Hrachovec, Marie Belejová, Tomáš Kilián, doc. MUDr. Ivana Oborná Ph.D

Klin Farmakol Farm. 2005;19(4):221-224  

Hormonal contraception is one of the basic methods of family planning. In addition to its contraceptive action, hormonal contraception also brings therapeutic effects. The article gives a brief overview of current methods of hormonal contraception, their therapeutic use, side effects and contraindication.

Combined oral contraceptive drugs with positive influence on skin complexion and function from dermatological viewpoint

Jarmila Rulcová

Klin Farmakol Farm. 2005;19(4):225-228  

Acne vulgaris combined usually with seborrhoea and in some persons with signs of hyperandrogenaemia ranks among the most common conditions in adolescents. In spite of the fact that in females suffering from acne, hyperseborrhoea, and mild forms of hirsutism serum androgen levels are usually not elevated, treatment with combined contraceptive drugs is mostly effective. Drugs contaning anti-androgenic components are the most suitable ones due to the blocking effect on the receptor level for androgens. The activity of the enzyme 5 alpha-reductase is markedly diminished. The most considerable anti-androgenic activity was observed in cyproteronacetate,...

Osteoporosis: goals of treatment

Jan Štěpán

Klin Farmakol Farm. 2005;19(4):229-234  

Ageing may be accompanied by osteoporosis which is not an unavoidable consequence of ageing. There are no characteristic clinical symptoms of osteoporosis. However, osteoporosis may result in low-trauma fractures. Vertebral and hip fractures result in untimely death, disability and dependence of afflicted patients. Osteoporosis can be early diagnosed, prevented and treated before fractures occur. It should not be treated before conclusively diagnosed. The pharmacological treatment of osteoporosis should be stratified with respect to the main factors of the 10-year absolute risk of fracture, i.e. bone loss, age and prevalent fracture.