Vážené dámy a pánové, kolegové a kolegyně,

MUDr. Milan Odehnal, MBA

Klin Farmakol Farm. 2013;27(2):55  

Issues of possible risk perception of medications in patients taking nonsterodial anti-inflammatory drugs/analgesics

Ján Gajdošík, Darina Brukkerová, Milan Kriška, Marián Zelina

Klin Farmakol Farm. 2013;27(2):57-60  

The aim of the survey was to identify the risk perception of nonsteroidal anti-inflammatory drugs (NSAIDs) by patients. We used the method of questionnaire survey of 400 randomly selected patients, evaluated by methods of descriptive statistics. The results present a diverse range of views, confirm a high interest of respondents in the problem, and can become a good starting point for extending the survey to other areas of risk perception of medication use. Enough information about the risks of medication use by patients and identification of critical moments in risk perception of medications are prerequisites for improving health care and...

Dry eye syndrome

Milan Odehnal, Jiří Malec

Klin Farmakol Farm. 2013;27(2):61-67  

Dry eye is one of the most common eye diseases. Its etiopathogenesis is multifactorial with close links to local and systemic diseases. The main cause of dry eye are pathological changes leading to instability of the tear film. Secondarily, these processes are reflected in changes to the surface of the eye. Genetic predisposition, age, gender, environmental impact, but also other factors such as wearing contact lenses, eye pathologies, systemic diseases, hormonal influences, psychosomatic aspects, the effects of some drugs, and more play the role in the development of dry eye. Patient with dry eye suffer with burning and cutting, transient...

Age-related macular degeneration

Helena Štrofová, Karel Sedláček, Alena Jarošová, Zora Dubská

Klin Farmakol Farm. 2013;27(2):68-74  

Age-related macular degeneration Age-related macular degeneration is an ocular disorder that leads to the deterioration of the center of the retina, resulting in loss of central vision. The risk of age-related macular degeneration increases with age, as the name suggests. Age-related macular degeneration usually produces a slow, painless loss of vision. In rare cases, however, vision loss can be sudden. There are two types of age-related macular degeneration: wet and dry. Various forms of the disease, etiopathogenesis as well as diagnosis and therapy are discussed in this review article.

Optic neuritis and multiple sclerosis

Milana Ampapová, Radek Ampapa

Klin Farmakol Farm. 2013;27(2):75-79  

Cerebrospinal multiple sclerosis is a chronic autoimmune disease affecting thousands of patients, particularly young ones aged 20 to 40, in the Czech Republic. The ophthalmologist most commonly encounters multiple sclerosis in patients with ongoing optic neuritis. A correct algorithm of timely diagnosis and treatment of optic neuritis is essential in minimizing permanent consequences in the patient and optimally adjusting long-term treatment of multiple sclerosis. Early initiation of immunomodulation therapy is the only option to prevent the progression of inflammation and, secondarily, neurodegeneration, which, as a result, may lead to delaying...

Strategies of risk assessment of biological agents with aspect to rheumatoid arthritis

Milan Kriška, Jozef Rovenský

Klin Farmakol Farm. 2013;27(2):80-83  

The aim of the review is to inform about harmful effects of biological agents during the treatment of RA. The increasing number of new biological agents presents a challenge in terms of their rational selection given their high cost as well as relative risk during long-term treatment.

Pharmacology of golimumab and its use in treating patients with rheumatoid arthritis

David Suchý

Klin Farmakol Farm. 2013;27(2):85-88  

The introduction of tumor necrosis factor-α (TNF-α) inhibitors represented a significant progress in the management of rheumatoid arthritis (RA) and other chronic inflammatory diseases. Golimumab a novel anti-TNF-α monoclonal antibody, has demonstrated significant efficacy in randomized, double-blind, placebo-controlled phase III trials in the treatment of RA, psoriatic arthritis (PsA), and ankylosing spondylitis (AS) when administered subcutaneously once every four weeks. This review summarizes the development of golimumab, its pharmacokinetic properties and clinical evidence achieved with golimumab in treatment of patients...

Indocyanine green: properties, current use and tTrends in clinical practice

Roman Kufa

Klin Farmakol Farm. 2013;27(2):89-91  

Indocyanine green (ICG) is one of the types of fluorescent dyes (fluorophores, fluorochromes). It is a chemical compound containing a reactive group capable of reacting with nucleophilic groups. The principle of fluorescence is the emission of energy in a very short time, caused by the effect of radiation. Each fluorescent substance is characterized by two types of spectra – an excitation and an emission spectrum. ICG has an excitation and emission spectrum in the near infrared region, hence the so-called NIR (near infrared) fluorophores. ICG is the only NIR dye that has been certified by the FDA (U.S. Food and Drug Administration) for...

Papulopustular exanthema as an adverse effect of cetuximab

Kateřina Kučerová, Jaroslav Urbánek

Klin Farmakol Farm. 2013;27(2):92-94  

The monoclonal antibody cetuximab, an inhibitor of epidermal growth factor receptor (EGFR), has been effectively used to treat various types of cancer. However, these agents frequently cause skin toxicity, which is due to the expression of the EGFR in the skin. This adverse effect impairs the quality of life of cancer patients and, in severe cases, requires dose reduction, or rarely, even discontinuation of treatment. Therefore, timely initiation of anticancer therapy is important.