Clinical Pharmacology and Pharmacy, 2017 (vol. 31), issue 2
Original articles
Purpose of the study – The aim of our study was to evaluace the impact of Neodoplpasse infusion postoperatively on the clot forming process
Tomáš Vymazal, Jan Beroušek
Klin Farmakol Farm. 2017;31(2):3-6 | DOI: 10.36290/far.2017.009 
Methods: Since October 2014 until June 2015, we prospectively enrolled 207 patients who were admitted to our intensive care unitdue to the postoperative care. All the patients underwent hip, knee or column surgery and abdominal surgery from laparotomia.During 90 minute intravenous infusion, Neodolpasse 250 mL was administered to all the pacients The blood samples were takenbefore, 2 and 4 hours after the Neodolpasse infusion to rotational tromboelastometry evaluation.Results: Despite of a large heterogenity of our cohort in age, lenght and type of surgery, we did not observe any statisticallysignificant differences in the clot forming, development...
Review articles
Macrolides Drug Interactions in 2017
Michal Prokeš, Ondřej Suchopár, Josef Suchopár
Klin Farmakol Farm. 2017;31(2):7-13 | DOI: 10.36290/far.2017.010
Macrolide antibiotics are popular antibiotic but they cause numerous drug-drug Interactions. Clarithromycin and roxithromycinare inhibitors of CYP3A4. This can harm patients using simvastatin, atoarvastatin, verapamil, diltiazem and other substrates ofCYP3A4. Clarithromycin also inhibits P-glycoprotein, which increase plasma levels of digoxin, trazodon, sildenafil, omeprazol andglibenclamid. Clarithromycin and azithromycin prolong QT interval and can cause arrhythmia torsade de pointes, which can bepotentiated by other drugs with similar action, such as amiodarone, sotalol, haloperidol and others. The close cooperation betweenprescribing physicians,...
Abstract
Monika Laššánová
Klin Farmakol Farm. 2017;31(2):14-17 | DOI: 10.36290/far.2017.011
From the perspective of pharmacodynamics and pharmacokinetic actions of drugs, there are clear differences between the genders.These differences have the potential to alter the efficacy, safety and even perception of risk of pharmacotherapy. Past research hasshown that women tend to reach a higher plasma concentration of administered drug than males. This can be as a direct resultof; distribution difference between genders, total body water capacity, the percentage of adipose tissue, renal blood flow andlastly due to metabolic activity of the individual. The pharmacodynamics differences between the genders need to be more thoroughlystudied, however,...
Summary
Pavel Štourač
Klin Farmakol Farm. 2017;31(2):18-22 | DOI: 10.36290/far.2017.031
We use for the treatment of relapsing-remitting course of multiple sclerosis the drugs with different mechanisms of action anddifferent clinical efficacy and safety profile. The treatment algorithm involves current clinical status of the patient and long-termefficacy and safety of the drug. The available drugs are as following; interferon beta-1a (IFNβ-1a), interferon beta-1b (IFNβ-1b),glatiramer acetate(GA), teriflunomide, dimethylfumarate, fingolimode, natalizumab and alemtuzumab.
Apixaban has been available for the treatment of venous thromboembolic disease for more than two years
Debora Karetová, Jan Bultas
Klin Farmakol Farm. 2017;31(2):23-26 | DOI: 10.36290/far.2017.014
Apixaban – a direct, oral, selective activated factor Xa inhibitor – has been approved since the year 2014 for the treatment ofacute venous thrombosis and the so-called low-risk pulmonary embolism (in addition to the registration for the prevention ofsystemic embolization in non-valvular atrial fibrillation and the prevention of venous thromboembolism in orthopaedics). It isan effective and very safe option for oral monotherapy since the establishment of the diagnosis of thromboembolic disease inboth outpatient and inpatient settings.
Herpesviruses and resistance to antiherpetics
Miroslav Fajfr, Vlasta Štěpánová
Klin Farmakol Farm. 2017;31(2):27-30 | DOI: 10.36290/far.2017.012
Herpesviruses belong to important pathogens in immunosuppressed population, which lead to increased consumption of antiherpeticsand of course also in increased level of resistant viruses to these therapeutics. This paper review basic informationsabout the most important members of antiherpetics, basic mechanisms resistance to antiherpetics and up to date knowledgeabout resistance prevalence and genomic changes associated to resistance.
Case reports
Abstract
Ľubica Cibičková, Miroslava Jelínková
Klin Farmakol Farm. 2017;31(2):31-33 | DOI: 10.36290/far.2017.013
Metoclopramide is a widely used and potent drug. It is indicated in many cases, but it should always be administered with respectto its potential side effects. This case report describes the development of fatigue, drowsiness and akathisia with gradualprogress into Parkinson´s syndrome, anxiety and depression. The therapy of these severe side effects included amantadine andclonazepam followed later by antidepressants.