Vzdělávání lékařů v oboru klinická farmakologie

doc. MUDr. Karel Urbánek, Ph.D.

Klin Farmakol Farm. 2024;38(4):136  

Benefit of innovative therapy in patients with cystic fibrosis

Mária Kolesárová, Michaela Križová, Dana Marcinčáková, Zuzana Mačeková

Klin Farmakol Farm. 2024;38(4):137-144 | DOI: 10.36290/far.2024.021  

Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by a genetic mutation of the gene for CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), which encodes a protein - CF transmembrane conductance regulator ensuring, among other things, the movement of chloride ions through the cell membrane. The clinical picture of the disease is characterized by chronic inflammation of the bronchopulmonary system, pancreatic insufficiency and increased salt content in sweat. The aim of the work was to determine the benefit of innovative combined therapy with CFTR protein modulators ivacaftor/tezacaftor/elexafactor (Kaftrio) in combination...

Comprehensive pain management in pediatric burn patients: combining pharmacological and non-pharmacological approaches

Júlia Bartková, Ema Knezovičová, Katarína Kentošová, Anička Príbojová, Barbora Karoľová

Klin Farmakol Farm. 2024;38(4):150-155 | DOI: 10.36290/far.2024.023  

Pain management in pediatric burn patients requires a comprehensive approach that incorporates both pharmacological and non-pharmacological methods. This article provides an overview of specific pharmacological medications used in the treatment of burn-related pain, with a focus on their dosages and safety profiles. Opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), and paracetamol play a key role in effective pain control. Additionally, the importance of non-pharmacological methods, such as virtual reality, music therapy, aromatherapy, and distraction techniques, is emphasized for improving overall treatment outcomes. The article highlights...

Molecular mechanisms and pharmacology of cannabinoids: from theory to practice

Marek Lapka

Klin Farmakol Farm. 2024;38(4):156-160 | DOI: 10.36290/far.2024.024  

Cannabinoids, active compounds of the Cannabis plant, influence a wide range of physiological processes through the endocannabinoid system, comprising CB₁ a CB₂ receptors, endogenous ligands, and regulatory enzymes. This review summarizes the mechanisms of action of phytocannabinoids, synthetic cannabinoids, and endo­cannabinoids, including their pharmacological properties, therapeutic potential, and associated risks. The article also discusses the toxicity of synthetic cannabinoids, highlighting the public health threat posed by their recreational use. Finally, it explores current clinical applications of cannabinoids,...

Pharmacological profile of fosfomycin

Jitka Rychlíčková

Klin Farmakol Farm. 2024;38(4):145-149 | DOI: 10.36290/far.2024.022  

Fosfomycin, an antibiotic discovered in 1969, is experiencing a renaissance, parti­cularly in the treatment of infections caused by multidrug-resistant Gram-negative pathogens. The combination of its unique mechanism of action, broad spectrum of activity, favourable level of resistance, good tissue penetration and low incidence of adverse events makes it a valuable therapeutic alternative. The aim of this article is to summarize the main pharmacological characteristics of fosfomycin with emphasis on its intravenous form.