Klin Farmakol Farm. 2010;24(4):178-180

Skin Cancer and Renal Transplantation - University Hospital Olomouc Transplant Center Statistical Analysis Outcomes

Lucie Kalinová^1,3, Ondřej Májek², Daniel Stehlík³, Karel Krejčí⁴, Petr Bachleda¹

¹ II. chirurgická klinika, FN Olomouc

² Institut biostatistiky a analýz, Masarykova univerzita, Brno

³ Oddělení plastické a rekonstrukční chirurgie, FN Olomouc

⁴ III. interní klinika, FN Olomouc

Aim: To provide the evaluation of skin cancer incidence and to identify factors associated with an increased incidence of skin cancers in

renal transplant recipients followed in the University Hospital Olomouc Transplant Center.

Methods: A retrospective data analysis of medical records of all transplant patients who underwent renal transplantation in the period

1984–2009 and were followed in the University Hospital Olomouc Transplant Center (n = 603). In patients who were reported to have

a diagnosis of cancer date and type of diagnosis were recorded. The cohort was linked with the National Cancer Registry of the Czech

Republic. Patients with a diagnosis of cancer prior to transplantation were excluded from the study. Statistical analysis was performed

using the Mann – Whitney and Chi square test.

Results: In the study population we found cancer de novo after transplantation in 92 patients. Skin cancer had a total of 55 patients.

Fifty-two (94.5 %) patients had non-melanoma skin cancer, 2 (3.6 %) patients had malignant melanoma, and we uncovered one case of

merkel cell carcinoma of the skin. Out of all evaluated parameters, the patient‘s age at the time of transplantation and type of immunosuppressive

therapy showed statistical significance.

Keywords: skin cancer, transplantation, immunosuppression

Published: December 31, 2010  Show citation