Slovo úvodem

prof. MUDr. Milan Kolář, Ph.D.

Klin Farmakol Farm. 2010;24(4):171  

Contemporarly view on emollients utilization

Renata Blechová, Božena Macešková

Klin Farmakol Farm. 2010;24(4):174-177  

Emollients are drugs involved in the group of dermalologics, used for the local application in the case of dry skin, xerodermia and the cornification failure. The aim of this study was to assess the use of emolients analyzing the dispensation data in the pharmacies, and by means of questionaires sent to 75 senior residental homes (SRH) located in different parts of the CR. The study was carried out between January 2009 and Juni 2010. As the result of the study we can conclude, that the most frequently dispensed drug in the pharmacies was Excipial U lipolotio (on medical prescription and as the over the counter drug as well). It was the drug...

Skin Cancer and Renal Transplantation - University Hospital Olomouc Transplant Center Statistical Analysis Outcomes

Lucie Kalinová, Ondřej Májek, Daniel Stehlík, Karel Krejčí, Petr Bachleda

Klin Farmakol Farm. 2010;24(4):178-180  

Aim: To provide the evaluation of skin cancer incidence and to identify factors associated with an increased incidence of skin cancers in renal transplant recipients followed in the University Hospital Olomouc Transplant Center. Methods: A retrospective data analysis of medical records of all transplant patients who underwent renal transplantation in the period 1984–2009 and were followed in the University Hospital Olomouc Transplant Center (n = 603). In patients who were reported to have a diagnosis of cancer date and type of diagnosis were recorded. The cohort was linked with the National Cancer Registry of the Czech Republic. Patients...

Influence of antibacterial treatment on the development of bacterial resistence

Milan Kolář, Karel Urbánek, Vojtěch Hanulík, Vladimíra Vojtová

Klin Farmakol Farm. 2010;24(4):181-183  

The review deals with a question of bacterial resistance to antibiotics. Most important phenotypes of the bacterial resistance are described, including the real examples of the important pathogens’ resistance development in the University Hospital in Olomouc, Czech Republic. On the basis of these data, the principles of antibacterial treatment are stated.

Options fluorochinolones in current clinical practice

Vojtěch Hanulík, Miroslava Htoutou Sedláková, Jana Petrželová, Milan Kolář

Klin Farmakol Farm. 2010;24(4):184-186  

Fluoroquinolones are purely synthetic agents with antibacterial effects. For their excellent properties and a broad spectrum of activity, they are well established in the treatment of many bacterial diseases. Fluoroquinolones are commonly used in both human and veterinary medicine. However, their application is associated with potential development and spread of bacterial resistance, impairing the activity of these excellent agents.

Daptomycin - a new antibiotic for the treatment of serious infections caused by certain gram-positive bacteria

Vilma Marešová, Pavla Urbášková

Klin Farmakol Farm. 2010;24(4):187-189  

Daptomycin is a cyclic polypeptide, a new antibiotic with bactericidal activity in vitro against many gram-positive bacteria. This well-tolerated antibiotic is used for intravenous treatment of serious infections caused by staphylococcus and streptococcus, or strains, resistant and multidrug-resistant to other antibiotics. The indication for daptomycin include serious skin and soft tissues, including forms and right bakteremických endocarditis caused by Staphylococcus aureus.

Reliability of computer programs providing support for electronic prescribing of drug interactions

Michal Prokeš, Josef Suchopár

Klin Farmakol Farm. 2010;24(4):190-196  

Computer programs offering electronic prescription support (EPP) are in developed countries widely dispersed, but they are not exploited in an optimal way routinely. In this paper elaborated on the basis of foreign studies we describe the rate of the change of physicians ´s prescribing habbits evoked by EPP programs on the field of potential drug interactions (PLI) and also is shown how physicians percieve such programs. Physicians consider these programs being helpfull but are worried about credibility of information provided by these programs and consider some warnings issued by these programs as irrelevant and bothering. In the second part...

Biological therapies in rheumatology

Hana Ciferská, Pavel Horák, Jan Strojil, Martina Skácelová

Klin Farmakol Farm. 2010;24(4):197-206  

The goal of this short review is to inform readers about the position and utilization of biological agents in therapy of selected rheumatic disorders. The advancement of biological agents in last two decades and their introduction in clinical practice led to prognosis improvement in very active rheumatoid and psoriatic arthritis and ankylosing spondylitis patients, who did not respond to conventional therapy. The authors discuss the selected biological agents – their indications, the follow up of their effects, the adverse events and pitfalls of their usage.

Risk management systems and restricted drug distribution systems in the U. S. A.

Jozef Kolář

Klin Farmakol Farm. 2010;24(4):208-213  

Risk management systems – risk minimization action plans (RiskMAPs), risk evaluation and mitigation strategies (REMS), risk management plans (RMPs) and restricted drug distribution systems (RDDSs) are discussed. The author describes several the most famous programs like APPRISE (darbepoetin alfa, Aranesp®, epoetin alfa, Epogen®, Procrit®), ATAP (alglucosidase alfa), E.A.S.E.™ (alvimopan, Entereg®), FOCUS (fentanyl, Onsolis™), LEAP (ambrisentan, Letairis®), Lumizyme ACE (alglucosidase alfa, Lumizyme™), MTAP (alglucosidase alfa, Myozyme®), NEXUS (romiplostim, Nplate™), PLUS (abarelix,...

Prevention and treatment of secondary hyperparathyroidism in chronic kidney disease

František Švára

Klin Farmakol Farm. 2010;24(4):214-219  

The current approach to secondary hyperparathyroidism (SHPT) in chronic kidney disease is much broader than in the past. The disorder is now considered to be a part of a multisystem disease which implies not only deviations in the laboratory markers of bone metabolism, but also the formation of extraosseous (predominantly vascular) calcifications and abnormalities in bone volume, mineralization and turnover. This comprehensive view of the issue was the reason why a new term has been introduced: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Based on the results of large mortality studies, current treatment for this disorder is...

Drug interaction between lamotrigine and valproic acid used at delivery and during lactation - a case report

Ivana Kacířová, Milan Grundmann, Hana Brozmanová

Klin Farmakol Farm. 2010;24(4):222-225  

Purpose: In our case report we show a woman treated by combination of lamotrigine and valproic acid at delivery and during first postnatal month. We analyzed maternal clearance, transport through the placenta and to maternal milk and exposure in breastfed infants. Methods: The patient was treated with combination of lamotrigine and valproic acid. Milk and blood samples from the mother and her breastfed infant were collected at delivery and during first postnatal month. Maternal serum levels were used for the estimation of apparent oral clearance. Paired milk and maternal, infant and maternal and infant and milk concentrations were used for...

Komentář ke článku Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lots

Vladimíra Vojtová

Klin Farmakol Farm. 2010;24(4):220  

Kongres ovládly nové poznatky z farmakologie

Petr Petr

Klin Farmakol Farm. 2010;24(4):226