Problematika adherence k farmakoterapii z pohledu psychiatra

prof. MUDr. Eva Češková, CSc.

Klin Farmakol Farm. 2024;38(1):4  

Betablockers and CV disease - controversy 2023

Jiří Vítovec, Monika Špinarová

Klin Farmakol Farm. 2024;38(1):5-8 | DOI: 10.36290/far.2024.001  

Beta-blockers are used for a wide range of cardiovascular diseases (CVD) - from arterial hypertension to heart failure. Recently, however, a number of analyzes and information have appeared that question the role of beta-blockers in some indications. We provide an overview of the controversies that have arisen around beta-blockers in the treatment of heart failure, hypertension, arrhythmias, in the secondary prevention of ischemic heart disease, and in perioperative administration to patients during non-cardiac operations.

Errors occurring during nurse administration of medicines to hospitalized patients: an observational-interventional study

Kateřina Malá-Ládová, Josef Malý, Ondřej Tesař, Martin Doseděl, Iva Brabcová, Hana Hajduchová, Martin Červený, Radka Prokešová, Ivana Chloubová, Jiří Vlček, Valerie Tóthová

Klin Farmakol Farm. 2024;38(1):9-14 | DOI: 10.36290/far.2024.002  

Introduction: The medication administration to hospitalized patients is critical in the delivery of healthcare services and is associated with the occurrence of various categories of errors with real impact on patient health and healthcare costs. Aim: The aim of this study was to analyse the impact of interventions and their sustainability on the prevalence of errors asso­ciated with medication administration by nurses to hospitalized patients. Methods: Data were obtained from an observational intervention study conducted from 2020 to 2023 and analysing medication administration by nurses in one of the Czech hospitals. Data collection was done by direct...

Medication adherence - the way to understand patients

Patricia Schnorrerova, Petra Matalova, Martin Wawruch

Klin Farmakol Farm. 2024;38(1):15-21 | DOI: 10.36290/far.2024.007  

The aims of this review are to explore the critical issue of medication adherence, which is essential for effective healthcare outcomes but remains a significant challenge. The review delves into the diverse aspects of non-adherence, including patient perceptions, economic challenges, and complex treatment regimens. It emphasizes the importance of accurate adherence assessments, particularly through self-report questionnaires and retrospective database analyses. The review also explores the historical evolution of adherence concepts and highlights the critical role of pharmacists in educating patients and managing medication regimens. The importance...

Hypertensive disease in the context of adherence and nonadherence to treatment

Iveta Ondriová, Terézia Fertaľová, Lívia Hadašová

Klin Farmakol Farm. 2024;38(1):22-25 | DOI: 10.36290/far.2024.004  

Arterial hypertension is the most frequently occurring cardiovascular disease, it represents a serious risk factor for other cardiovascular diseases. The treatment of any disease cannot be done without the adherence of the patient himself. Through adherence, the patient demonstrates the ability to adapt and comply with individual regulations and requirements from the doctor, which increases the probability of achieving the set treatment goals and prevents possible complications.

Adherence to therapy in chronic pulmonary diseases with a focus on COPD

Martin Poruba

Klin Farmakol Farm. 2024;38(1):26-30 | DOI: 10.36290/far.2024.003  

Chronic obstructive pulmonary disease is one of the most significant causes of morbidity and mortality worldwide. Proper use of medicine is the mainstay in COPD pharmacotherapy. According to the studies, there is a lack of adherence to therapy for chronic diseases. One of the relevant reasons for poor adherence and treatment failure could be difficulty in drug administration. This review is focused on published literature on methods of checking adherence and also studies focused on adherence and proper handling of COPD medication.

Effective interventions to increase adherence to inhaled therapy in patients with bronchial asthma - a review article

Karolína Nálevková, Tereza Hendrychová, Vladimír Koblížek, Vratislav Sedlák, Josef Malý

Klin Farmakol Farm. 2024;38(1):31-37 | DOI: 10.36290/far.2024.005  

Bronchial asthma, a chronic pulmonary disease, has a major impact on the patient's daily life. Medication adherence and correct inhalation technique are essential to achieve the goals of therapy. The aim of this paper is to provide a review of published literature evaluating the effect of pharmacist-led interventions on medication adherence or inhalation technique in adult patients with bronchial asthma. A total of 23 studies were identified by a literature search of PubMed and Scopus databases. The analysis of the selected studies suggested that pharmacist-led intervention in any form had a positive impact on both above mentioned oberved phenomena...

Pharmacological profile of mavacamten in the treatment of hypertrophic obstructive cardiomyopathy

Marek Lapka

Klin Farmakol Farm. 2024;38(1):38-45 | DOI: 10.36290/far.2024.006  

Mavakamten is a selective, allosteric and reversible inhibitor of cardiac myosin. In this way, it modulates the number of myosin heads that enter the state of onset of contraction, thereby reduce the likelihood of the formation of systolic and residual diastolic cross bridges during contraction. The molecule is currently approved and indicated for the treatment of symptomatic hypertrophic obstructive cardiomyopathy (oHCM) (New York Heart Association, NYHA, class II-III) in adult patients. A large clinical study is currently underway, which will attempt to supplement the long-term data on the safety and efficacy of mavacamten in the mentioned indication.