Dermatologické zamyšlení

Jarmila Rulcová

Klin Farmakol Farm. 2006;20(4):175  

THE CONSUMPTION OF ANTIMICROBIAL DRUGS AND ANTIMYCOTICS AT THE SURGICAL WARD OF THE HOSPITAL AND POLICLINIC DURING 2000-2004

doc. RNDr. Jozef Kolář CSc, Andrea Bartasová, Dana Mazánková

Klin Farmakol Farm. 2006;20(4):178-183  

Objective: Analysis of prescription and consumption of antimicrobials and antimycotics in a surgical ward at the Hospital and Policlinic during the years 2000–2004 in terms of individual groups of antimicrobials and medicines in the frame of these groups and economic indicators, as the share in total consumption and spending on medicinal products in the first quarter of the period 2000–2004. Methods: Data for calculating defined daily doses (DDD) were obtained by processing of hospital order forms with the help of pharmacy software. This entry referred per 100 days of hospitalization. The basis for price calculation of one DDD of individual...

MANAGEMENT OF METASTATIC BONE DISEASE FROM PROSTATIC CANCER IN TWO ONCOLOGICAL CENTERS IN CZECH REPUBLIC - RETROSPECTIVE ANALYSIS

Veronika Vokatá, Aleš Kuběna, Jiří Vlček

Klin Farmakol Farm. 2006;20(4):184-189  

Aim: Bone metastases occur in approximately 85 % of patients with prostate cancer and represent high risk of SRE development (Skeletal Related Events), mainly pathologic fractures. Bone metastases and these events result in bone pain and decreasing quality of life. Bisphosphonates are potent compounds which decline the occurrence and relapse of SRE. The aim of study was to evaluate the therapy with bisphosphonates in patients with metastatic bone disease from prostate cancer. Methods: Retrospective observation study is involving two university oncological centers in Czech Republic. The data for analysis were obtained from medical records of...

Drug utilization study methodologies

Blanka Kořístková, Milan Grundmann

Klin Farmakol Farm. 2006;20(4):219-222  

Drug utilization expresses the exposition to a drug in the relationship to a given population group, in a given period and in a certain socio-economical background. The volumes of the drugs distributed and of the prescription drugs issued are available on the national level. The amount of drugs issued on request forms in a certain medical institution is available on the local level. The utilization of non-prescription drugs is available in a local pharmacy. It is also possible to study the number of prescriptions according to the patient’s documentation. Drug utilization may be expressed in numbers of packages, prescribed daily doses, defined...

Komunikácia pri riziku liekov

Monika Laššánová, Roman Hudec, Martin Wawruch, Jana Tisoňová, Lýdia Božeková, prof. MUDr. Milan Kriška DrSc

Klin Farmakol Farm. 2006;20(4):226-227  

8. konference klinické farmakologie, 13. konference terapeutického monitorování hladin léčiv, 10. konference DURG, Sympozium Nutraceutika 06

Jiří Kopecký

Klin Farmakol Farm. 2006;20(4):228  

Zpráva z celosvětového farmakologického kongresu IUPHAR 2006

Zbyněk Svoboda

Klin Farmakol Farm. 2006;20(4):229-230  

EVALUATION OF ADVERSE DRUG REACTIONS

Roman Hudec, Lýdia Božeková, prof. MUDr. Milan Kriška DrSc, doc. MUDr. Viera Kořínková CSc, Tatiana Magálová

Klin Farmakol Farm. 2006;20(4):223-225  

Causality assessment is the process of further evaluation of adverse drug reaction in Slovak State Institute of Drug Control. We brought different views and classifications. According to Uppsala Monitoring Centre of the WHO, causality is divided into six categories. The most reports are classified as probable, or possible. Causality assessment is a part of pharmacovigilance and help us to estimate severity of spontaneus reports. This process is difficult and we have to remember that we cannot quantify or eliminate uncertainty, but can help to type several adverse drug reactions.

THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY AND HER IMPLICATION IN MALIGNANT TRANSFORMATION OF SOLID TUMORS

Ivo Überall, Zdeněk Kolář

Klin Farmakol Farm. 2006;20(4):190-196  

The epidermal growth factor receptor (c-erbB/HER) system comprises the epidermal growth factor receptor (c-erbB-1/EGFR/HER-1) and three other homologues c-erbB-2-4/HER-2-4. This receptor system plays a critical role in apoptosis, migration, cell invasivity and metastasis, proliferation, adhezivity and differentiation of the cells. Changes of statut this receptors has been associated with poor prognosis in cancer of numerous tumors. Recently, these receptors have been intensely studied to understand is their importance in cancer biology and as therapeutic targets, and many specific and non-specific c-erbB inhibitors are developed for use.

BOHEMINE IN VITRO CYTOTOXIC ACTIVITY IN PRIMARY TUMOUR CELLS

Libuše Stýskalová, MUDr. Karel Cwiertka, Věra Nosková, Anna Janošťáková, Lenka Radová, prof. MUDr. Vladimír Mihál CSc, Marián Hajdúch

Klin Farmakol Farm. 2006;20(4):197-201  

Background: Cyclin dependent kinases complexed with cyclins trigger eukaryotic cell cycle proliferation by phosphorylation of specific target protein. Synthetic inhibitors of cyclin dependent kinases (CDKIs) as olomoucine (OC), bohemine (BOH), R-roscovitine (ROSC, seliciclib, CYC202) etc., are typical representatives of drugs, which can be used for control of cellular proliferation and clinical treatment of tumours. Aim: The purpose of this study was to assess the cytotoxic activity of the synthetic CDKI, bohemine, on human primary tumour cells and compare its potency with classic anti-cancer drugs. Methods: Malignant cells were isolated, after...

REVIEW OF TOPICAL CORTICOSTEROIDS IN DERMATOLOGY 1. POSSIBILITY OF THE TREATMENT SKIN DISEASES WITH CORTICOSTEROID PREPARATIONS

doc. MUDr. Marie Viktorinová CSc

Klin Farmakol Farm. 2006;20(4):202-210  

The article describes the mechanism of action of the topical corticosteroids, their pharmacodynamic effect, pharmacokinetic properties, local and systemic adverse effects.

THE TREATMENT OF ALOPECIA

MUDr. Helena Michalíková

Klin Farmakol Farm. 2006;20(4):211-214  

For a correct diagnosis and following treatment of increased hair loss a thorough history and physical exam of the patient are necessary. Based on these information we can usually divide alopecia on diffuse and focal. The article reviews basic facts and physiology of hair growth cycle, followed by a review of current treatment options of most frequent types of hair loss. Main focus is given to the most frequent hair loss, i.e. androgenic alopecia, which is treated differently in men and women. Because of typical finding we mention in detail problems of alopecia areata. Other clinical units are described briefly.