Farmakoterapie v kardiologii

doc. MUDr. Petr Heinc Ph.D

Klin Farmakol Farm. 2009;23(2):51  

Risky combinations of cardiovascular drugs in elderly patients and factors increasing the probability of their occurrence

Martin Wawruch

Klin Farmakol Farm. 2009;23(2):53-57  

Aim: The aim of the presented work was to analyse the prevalence of risky combinations of cardiovascular drugs. We assessed also patients ´ characteristics that increase the probability of their occurrence. Methods: We enrolled 600 patients aged 65 years or more admitted to the Department of Internal Medicine of the Hospital in Povazska Bystrica. To identify risky combinations of cardiovascular drugs the study of Vlahović-Palčevski et Bergman was applied. To define the most important patient’s characteristics associated with the occurrence of risky combinations of cardiovascular medications, the binary logistic regression model (SPSS for...

Treatment of acute heart failure

MUDr. Martin Hutyra Ph.D

Klin Farmakol Farm. 2009;23(2):59-63  

Acute heart failure syndromes have emerged as a leading public health problem worldwide. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The main classes of drugs used in pharmacotherapy are diuretics, vasodilators and inotropic agents. Noninvasive ventilation appears to be of benefit in the immediate treatment of patients with acute cardiogenic pulmonary edema and may reduce mortality. Some patients require cardiosurgical treatment or mechanical left ventricle assist device.

Contemporary view on antiarrhythmic drugs

doc. MUDr. Petr Heinc Ph.D

Klin Farmakol Farm. 2009;23(2):64-70  

There is evidence of good antiarrhythmic effect of available drugs for arrhythmia treatment but these drugs have no significant effect on mortality and all of them have some proarrhythmic effect. Radiofrequency ablation became the treatment method of the 1st. choice in patients with supraventricular tachyarrhythmias of reentry mechanism and in patients with ventricular tachyarrhythmias without structural heart disease presentation. Antiarrhythmic drug therapy is the treatment of the 2nd choice in these cases. Antiarrhythmic drug therapy is the treatment of the1st choice in patients with complex supraventricular and ventricular tachyarrhythmias...

Pharmacological’s medication of the peripheral vascular disease

MUDr. Jarmila Indráková, Lucie Kalinová

Klin Farmakol Farm. 2009;23(2):71-75  

Peripheral Vascular Disease (PVD), affecting estimatedly up to 20 % of the patients over 70 years, is in its less advanced stages (stage I and II of the Fontain classification) chiefly a predictor of increased cardiovascular mortality due to a high probability of collateral ischemic heart and brain disease. The more advanced stages of the disease limit the prognostically ill person significantly and they principally threaten the quality of life, not only by the possibly amputation of the limb. Atherosclerosis is a generalised disease, the basis of PVD therapy inheres in an agressive intervention of its risk factors and in the influence of its possible...

Current pharmacological options of embryoprotective therapy in infertile women

Robert Hudeček, Renáta Krajčovičová, Pavel Ventruba

Klin Farmakol Farm. 2009;23(2):76-82  

The paper provides a survey of the aetiology, differential diagnosis, and therapy of habitual abortion. Appropriate differential diagnosis facilitates the determination of the aetiological factor of infertility and subsequent targeted causal therapy. As our knowledge of the mechanisms underlying a physiological course of pregnancy increases, the individual aetiological factors related to habitual abortion are being reappraised. The dominant role of anatomic and infectious causes is on a decline giving way to an increasing incidence of immune-, genetically-, and haematologically-related habitual abortions. Diagnosing the causes of habitual abortion...

Can coffee consumption affect the risk of developing type 2 diabetes?

Ing. Martina Maxová

Klin Farmakol Farm. 2009;23(2):83-85  

Coffee can be considered as the most widely consumed beverage with a pharmacological effect worldwide, and the caffeine contained therein as the most commonly consumed psychoactive substance. The results of experimental as well as epidemiological studies investigating the effect of coffee and/or caffeine on metabolic disorders associated with insulin resistance indicate its positive effect; however, it is always necessary to take into account the amount of the caffeinated drink consumed, the making of the drink, and possible diseases in the patient who is to receive dietary advice from his physician. The mechanisms by which coffee exerts its positive...

Azole antimycotics: Mechanisms of drug-drug interactions

Lucie Krausová, Jiří Grim, Petr Pávek

Klin Farmakol Farm. 2009;23(2):86-89  

Altough the therapy of fungal infections has been developing for many years, searching of optimal drugs and pharmacotherapeutic approach is still desirable due to the increasing prevalence of systemic mycoses with high risk of mortality. In comparison with the past, currently we dispose of more efficacious drugs with lower adverse effects. Significant progress has been done in terms of reduction of adverse effects of azole antifungals and heightening of their specificity for pathogen. Nevertheless drug-drug interactions, which may occur in 95 % in patients treated with combination of azole antimycotics and other drugs, still complicate the pharmacotherapy...

Effect of drug budgets on drug prescription in Czech Republic in 2006

Michal Prokeš, Josef Suchopár

Klin Farmakol Farm. 2009;23(2):90-96  

Administrative interventions issued by Ministry of Health in Czech Republic in 2006 made physicians to save money on drug prescription more than in other years. While yearly growth of drug expenses and drug consumptions (in defined daily doses/1000 inhabitants/day) in 2001–2005 where +9 %, respectively +5 %, in 2006 these numbers where -8,7 %, respektively -7,4 % and in 2007 +13,9 %, respektively +22,9 %. The analysis of four therapeutically important drug groups and four less important drug groups discovered decline of consumption in 2006 and increase of consumption in 2007 in all of them (with a few exceptions). From these findings authors...

Komentář k článku Rizikové kombinácie kardiovaskulárnych liečiv

Michal Prokeš

Klin Farmakol Farm. 2009;23(2):58  

Zpráva z konference

Ivana Kacířová

Klin Farmakol Farm. 2009;23(2):97-98